HUGO MOSER RESEARCH INSTITUTE OVERVIEW

Kennedy Krieger’s scientists and researchers are leaders in the worldwide effort to prevent and treat disorders of the brain, spinal cord, and musculoskeletal system.  Our investigators continue to break new ground with innovative magnetic resonance imaging technology, investigate critical areas, such as the role of genetics in developmental disorders, and develop new treatment models and therapies. Kennedy Krieger is committed to sharing our knowledge that can be adapted and used by other healthcare organizations to benefit patients across the country and around the world.

Professional Training Overview

Kennedy Krieger dedicates substantial resources to increasing the number of qualified specialists in the fields of neurological and developmental disabilities. We also take seriously our responsibility not only to improve care through research, but to share that knowledge with others. That is why more than 400 individuals come here to train in a wide variety of disciplines each year. The goals of the Institute’s clinical training programs are twofold: 1) to train leaders in the field of neurodevelopmental disabilities and 2) to help ensure that there is a sufficient number of qualified professionals to meet the needs of children with special health care needs and their families. By training future generations of researchers and professionals – from undergraduate students to current staff – we are ensuring that children everywhere can receive the best possible care.

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Home › Research & Training
A National Research Resource Center for Functional Brain Imaging Technology
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The only children's hospital designated as a NIH National Research Resource for functional brain imaging, Kennedy Krieger is breaking new ground with innovative fMRI techonology.
Understanding Behaviors Through Observational Research
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Discovering the environmental and biological basis of behavior is crucial to understanding and improving treatment outcomes for a wide variety of developmental disorders.
Motion Analysis Research and Laboratory
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Using 3D modeling and other innovative technologies, our researchers are studying new methods to improve walking patterns in those with brain injuries.
IAN Research: Advancing Research, Empowering Advocates, Interpreting Findings
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The Interactive Autism Network (IAN) is the nation's largest online autism research effort. IAN Research collects data from families online and matches them to studies nationwide.

HUGO MOSER RESEARCH INSTITUTE OVERVIEW

Kennedy Krieger’s scientists and researchers are leaders in the worldwide effort to prevent and treat disorders of the brain, spinal cord, and musculoskeletal system.  Our investigators continue to break new ground with innovative magnetic resonance imaging technology, investigate critical areas, such as the role of genetics in developmental disorders, and develop new treatment models and therapies. Kennedy Krieger is committed to sharing our knowledge that can be adapted and used by other healthcare organizations to benefit patients across the country and around the world.

Participate in Research

Over the years, Kennedy Krieger’s scientists and researchers have made crucial medical discoveries that have led to innovative treatments and improved patient care for individuals with disorders of the brain, spinal cord and musculoskeletal system. Learn more about current research studies you can participate in by visiting our recruiting research studies page. Learn more.

Current Research Projects

Transcellular Degradation of Mitochondria in the Central Nervous System
Principal Investigator: Marsh-Armstrong, Nicholas
We recently made the surprising discovery that mitochondria from retinal ganglion cell axons are passed onto neighboring astrocytes for degradation in the optic nerve head of normal mice. We present...
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Relationship of MRI to ASIA Impairment Scale in Chronic Spinal Cord Injury
Principal Investigator: McDonald, John
Development of imaging correlates of the integrity of spinal cord white matter is needed for optimizing design of clinical trials in spinal cord injury and therapies for patients with chronic spinal...
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Advanced Restoration Therapies in Spinal Cord Injury 0186 - FY 08 - 09
Principal Investigator: McDonald, John
Evidence suggests that functional electrical stimulation (FES) can improve certain functions in the central nervous system (CNS) following injury or disease. Using FES-based therapies in spinal cord...
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Advanced Restoration Therapies in Spinal Cord Injury 0192 – FY07
Principal Investigator: McDonald, John
Recent evidence suggests that functional electrical stimulation (FES) can improve certain functions in the CNS following injury or disease. Our preliminary clinical observations utilizing FES...
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Localized Growth Factors Effects on Myelination by hESC Derived Oligodendrocytes in a Novel Microfluidic Platform
Principal Investigator: McDonald, John
In the central nervous system (CNS), the loss of protective myelin sheath surrounding axons, known as demyelination, is a major cause of sensory and motor function deficits in diseases such as...
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Developing New Multicolor Polypeptide MR Contrast Agents for Stem Cell Tracking
Principal Investigator: McMahon, Michael
Development of new contrast materials is important to expand the diagnostic capabilities of MR at the cellular and molecular level. In particular, providing information on cell migration, trafficking...
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16.4T Vertical Wide Bore Animal MR Imager
Principal Investigator: McMahon, Michael
We propose to acquire a 16.4 Tesla wide-bore vertical magnetic resonance (MR) small- animal scanner equipped with multi-coil receive capability. The overall goal is to upgrade the F.M. Kirby Research...
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Multi-Color Exchange Transfer Imaging of Drug Delivery Nanocarriers
Principal Investigator: McMahon, Michael
This project focuses on the design of biodegradable contrast agents, based on peptides and heterocycles, to be used for the labeling of drug delivery vehicles such as liposomes and polymeric...
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OIACEST Islet Cell Capsules for Immunoprotection, MR Detection, and pH Sending
Principal Investigator: McMahon, Michael
Good glycemic control is critical in reducing the end-stage complications of Type I Diabetes Mellitus (TIDM) and, for this reason, islet transplantation (ITx) has received considerable attention in...
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Novel Approaches for Investigating the Neurology of Autism: Detailed Morphometric Analysis and Correlation with Motor Impairment
Principal Investigator: Mostofsky, Stewart
In order to understand how to best diagnose and treat individuals with autism, it is important to identify the brain abnormalities associated with the disorder. Studies of postmortem brain tissue...
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Anomalus Motor Physiology in ADHD
Principal Investigator: Mostofsky, Stewart
The hypothesis of this study is that the neuromotor anomalies present in children with ADHD will be associated with deficient intracortical and interhemispheric inhibition of the motor cortex. This...
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Neurology of Deficient Response Control in ADHD
Principal Investigator: Mostofsky, Stewart
Building on evidence established in the initial grant period, the overall goals of the proposed study, “Neurology of Deficient Response Control in ADHD,” are to apply advanced neuroimaging and...
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Motor Skill Learning in Autism
Principal Investigator: Mostofsky, Stewart
Abnormalities on motor examination have often afforded valuable insights into developmental disorders of the brain; such abnormalities have been well documented in individuals with autism and, in...
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Tourette Syndrome Association Neuroimaging Consortium Pilot Study
Principal Investigator: Mostofsky, Stewart
Sponsored by TSA-WU-12-91. Important research on Tourette Syndrome (TS) is proceeding along several fronts, from gene-hunting to controlled trials of new treatments. The TSA has fostered...
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Pathogenesis of Rett Syndrome
Principal Investigator: Naidu, SakkuBai
This is an observational study of the natural history and clinical course of Rett Syndrome (RTT), a neurodevelopmental disorder primarily affecting females, caused by mutations in the MeCP2 gene. Our...
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Placebo-Controlled Trial of Dextromethorphan in Rett Syndrome
Principal Investigator: Naidu, SakkuBai
The overall goal of this study is to counter the effects of increased N-methyl-D-aspartate (NMDA)/glutamate receptors in MeCP2-mutation-positive Rett syndrome (RTT) subjects by use of a placebo-...
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Understanding the Brain Basis of Impaired Imitation Learning in Autism
Principal Investigator: Nebel, Mary Beth
In a developmental disorder such as autism (ASD), brain-based learning mechanisms vital to the acquisition of motor skills may contribute to impaired development of social and communicative abilities...
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The Role of the Transcallosal Pathway in Neuroplasticity Following Nerve Injury
Principal Investigator: Pelled, Galit
Peripheral nerve injury causes sensory dysfunctions that are thought to be attributable not only to the functional, cellular and biochemical events occurring in the peripheral nerve, but also to the...
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Adaptive Control of Epileptic Seizures Using A Genetically Encoded Sensor
Principal Investigator: Pelled, Galit
Sponsored by the National Institutes of Health (NIH) -- 1R01NS079288-01. About 35 percent of epileptic patients do not respond to antiepileptic drugs. Of these, only a quarter of them can be treated...
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Long-term plasticity and recovery in pediatric TBI rat model
Principal Investigator: Pelled, Galit
Abstract: Traumatic brain injury (TBI) is a leading concern in children and young adults in the United States, with more than 3,000 deaths and 29,000 hospitalizations annually (Centers for Disease...
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Accommodations for ADHD: Are They Effective in Reducing the Impact of the Disorder?
Principal Investigator: Pritchard, Alison
One of the most important functions served by a pediatric neuropsychological assessment is the provision of evidence-based recommendations and resources designed to reduce symptoms and improve...
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Pediatric Psychology and Neuropsychology Predoctoral Internship Training - Abstract
Principal Investigator: Reesman, Jennifer
Hearing loss or deafness affects more than 48.1 million individuals in the United States, with nearly 1 in 5 Americans displaying a hearing loss as defined by the World Health Organization criteria (...
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Life in Motion Wellness Program
Principal Investigator: Sachs, Christy
The benefits of sport and recreational activities for individuals with disabilities are well recognized from the standpoint of health and quality of life, yet there remains a lack of options. Kennedy...
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ArmAware: A Novel Device to Treat Motor Disorders
Principal Investigator: Salorio, Cynthia
The goal of this project is to develop a prototype of a novel device to treat hemiplegia. The award covers development costs of the initial prototypes.
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Kennedy Krieger Institute's Linked Clinical Research Center in Osteogenesis Imperfecta
Principal Investigator: Shapiro, Jay
As a participant of the Linked Clinical Research Centers (LCRC), the Osteogenesis Imperfecta (or) Program at the Kennedy Krieger Institute (KKI) brings an established record of multidiscliplinary...
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The Medical Evaluation of Autism in Preschoolers: Examining the Discrepancies between Parental and Clinical Impressions
Principal Investigator: Leppert, Mary
The proposed study will examine a clinic population of children being evaluated for early developmental delays in order to investigate how often parents and clinicians differ in their opinions...
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Clinical Diagnoses and Practices in a Preschool Developmental Clinic
Principal Investigator: Leppert, Mary
The purpose of the proposed study is to evaluate the frequency of developmental and behavioral disorders in preschool aged children who present to a developmental clinic, and to also observe trends...
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Disparities in Identification of Co-Morbid Diagnoses and Prescribing Practice in School Aged Children with ADHD: Comprehensive vs. Limited Evaluations
Principal Investigator: Leppert, Mary
We will conduct a retrospective chart review study of children 5-10 years of age, who present to the Kennedy Krieger Institute Center for Development and Learning for a new evaluation and are...
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Trajectory of Transition in Adolescents and Young Adults with Spina Bifida
Principal Investigator: Levey, Eric
The purpose of this interdisciplinary research project is to pilot an innovative multi-site study of the experiences, needs, and factors associated with positive transition in adolescents and young...
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Bowel and Bladder Continenece Among Children with Spina Bifida: A retrospective Study
Principal Investigator: Levey, Eric
Aim 1: To empirically assess the range of continence treatments and outcomes for children with spina bifida receiving usual care from an established multidisciplinary SB clinic. 1a. Given usual care...
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Cross-sectional investigation of reproductive and sexual function, knowledge, and behavior in adults with spina bifida
Principal Investigator: Levey, Eric
There is a paucity of data regarding endocrine function, fertility, sexual function, and sexual behaviors among adult patients with spina bifida. This study will help characterize the sexual and...
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Bladder stone risk analysis in patients with spina bifida
Principal Investigator: Levey, Eric
Spina bifida patients who have undergone bladder augmentation are at increased risk for the formation of bladder stones. Treating these bladder stones usually requires surgical intervention and...
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Wee cuddle and grow: how does it work?
Principal Investigator: Levey, Eric
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Prevalence of Latex Allergy in Children with Spina Bifida
Principal Investigator: Levey, Eric
This project has two goals: First, this study will assess how effective present day “latex avoidance” procedures have been in reducing latex sensitization among children who have been newly diagnosed...
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Development of an international database of patients with holoprosencephaly and related brain malformation
Principal Investigator: Levey, Eric
Holoprosencephaly (HPE) is an early embryonic malformation sequence of the vertebrate forebrain that occurs both as an isolated anomaly and in multiple malformation syndromes. HPE is characterized by...
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Bowel and Bladder Continence Among Children with Spina Bifida: A Prospective Study
Principal Investigator: Levey, Eric
The lack of effective bladder and/or bowel control is a significant barrier to the normal social and emotional development of children and adolescents with Spina Bifida. The study proposed in this...
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Continued Impairment in Adolescents Who Have Outgrown ADHD
Principal Investigator: Lipkin, Paul
Do adolescents who report that they have "outgrown" childhood Attention-Deficit/ Hyperactivity Disorder (ADHD) (diagnosed before age 10 years of age) continue to have symptoms of ADHD and impairment...
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Outcome of Inclusion in Children with Pragmatic Language Impairment
Principal Investigator: Lipkin, Paul
To determine if there is a relationship between the level of academic support and reading comprehension level by evaluating the difference in reading comprehension level in third grade in children...
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Developmental Surveillance and Screening Policy Implementation Project
Principal Investigator: Lipkin, Paul
The Developmental Surveillance and Screening Policy Implementation Project will select 15 pilot primary care pediatric practices to implement the AAP policy statement (anticipated publication of...
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Handedness in Children with Mental Disorders
Principal Investigator: Logue, Dora
Is there a higher incidence of left handedness in children with mental health disorders? Is the severity of mental health disorders greater in children who are left handed compared to right handed...
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Assessment of Neurocognitive Factors in Reading: Grades 4-8
Principal Investigator: Mahone, E. Mark
The focus of the current research is to examine the extent to and manner in which difficulties in component reading skills (both top down and bottom up), such as decoding accuracy, fluency, and...
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ADHD in Preschool Girls: Longitudinal Analysis of Neuroimaging and Behavior
Principal Investigator: Mahone, Mark
The overall goal of this project is to characterize the anomalous early development (brain, cognition, and behavior) of girls who present with the behavioral features of Attention Deficit...
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Neuroimaging of Motor Stereotypies in Children with Autism
Principal Investigator: Mahone, Mark
Complex motor stereotypies (i.e., apparently purposeless, rhythmical, repetitive movements) represent one of the core criteria—together with restricted interests, preoccupations, and rigidity—for...
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The Effects of ADHD (Beyond Decoding Accuracy) on Reading Fluency and Comprehension
Principal Investigator: Mahone, Mark
The central goal of this project is to understand how ADHD influences processing speed (as it relates to reading speed/fluency), working memory, and reading comprehension. Specifically, we will...
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ADHD in girls: neuroimaging and executive behavior
Principal Investigator: Mahone, Mark
This study is closed to participant accural and we are currently writing papers. This is a proposal to determine whether ADHD is associated with different brain anomalies/abnormalities in girls and...
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Neurobehavioral Late-Effects in Pediatric Brain Tumors
Principal Investigator: Mahone, Mark
Radiation Therapy (RT) has been largely responsible for improving the survival rates of children with certain types of brain tumors, although this has come at a cost in terms of the neurodevelopment...
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Frontostriatal Glutamate in ADHD: Neuropsychological and Behavioral Correlates
Principal Investigator: Mahone, Mark
Glutamate is an excitatory amino acid and the most abundant neurotransmitter in the brain. Glutamate levels are linked to a variety of neurological and psychiatric disorders, and have been implicated...
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The Incremental Validity of Neuropsychological Assessment in the Identification and Treatment of Attention Deficit/Hyperactivity Disorder
Principal Investigator: Mahone, Mark
The aim of this study is to determine the extent to which neuropsychological assessment contributes to the treatment of ADHD in terms of symptom reduction and quality of life. This is designed to be...
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Prevalence of Reading Difficulties: 4th-8th Grade
Principal Investigator: Mahone, E. Mark
The central goal of this project is to estimate the prevalence of various types of reading disability (RD) in the population of upper elementary and middle school students (grades 4 and 8). All data...
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Reading Disability in Grades 3 - 8: Neurocognitive Factors and Behavioral Assessment
Principal Investigator: Mahone, E. Mark
This project has two purposes: to examine the validity of a response-to-intervention (RTI) approach to identifying children with reading disabilities (RD) who are beyond the initial stages of...
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Genetic Influences on Sluggish Cognitive Tempo and Reading
Principal Investigator: Mahone, Mark
The overall goal of this pilot study is to examine the relationships between neuropsychological skills and genetic polymorphisms of children ages 8-15 years who display slowed processing speed in the...
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Neural Correlates of Mathematical Skills and Performance
Principal Investigator: Mazzocco, Michele
In a recent publication, we demonstrated that there are large individual differences in adolescents’ numerical acuity, and that 14-year-olds’ numerical acuity is retroactively predictive of their...
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SIMS -- Spinal Cord Injury Management System
Principal Investigator: McDonald, John
To define the treatment modality and co-factor variables which influence the response to Activity Based Restorative Therapies (ABRT) in individuals with Spinal Cord Injury (SCI). To define the dose...
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Localized Growth Factor Effects on Myelination by hESC Derived Oligodendrocytes in a Novel Microfluidic Platform
Principal Investigator: McDonald, John
Human embryonic stem cells (hESCs) are capable of growing into any type of cell in the body. Therefore, they may someday be used to repair or replace diseased tissue and even entire organs. Our focus...
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PTEN Mutation in Children with Autism Spectrum Disorder
Principal Investigator: Menon, Deepa
Recent case reports have described PTEN gene mutations in children with autism, mental retardation and macrocephaly.  In our study we propose to estimate the prevalence of PTEN mutation in a...
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The Study of Toddlers with Autism and Regression ( STAR) Protocol: Biomarkers of Inflammation and Immune activation in ASD- A pilot study
Principal Investigator: Menon, Deepa
Increased brain growth and size, along with neuroimaging findings in toddlers with ASD, suggest atypical cellular features that could be caused by a variety of neurological/systemic processes,...
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Creating a Pediatric Imaging-Genomics Data Resource
Principal Investigator: Mostofsky, Stewart
Along with investigators at 8 other sites across the U.S., we will assemble a large, cross-sectional imaging-genomics dataset. The major aim of our proposal is to create a database that is...
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Anomalus Motor Physiology in ADHD
Principal Investigator: Mostofsky, Stewart
The hypothesis of this study is that the neuromotor anomalies present in children with ADHD will be associated with deficient intracortical and interhemispheric inhibition of the motor cortex. This...
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Neurologic basis of inhibitory deficits in ADHD
Principal Investigator: Mostofsky, Stewart
Prevailing hypotheses implicate deficient response inhibition as one of the fundamental features driving the pathophysiology of ADHD. Results from studies of lesions in animals and humans led many...
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Tourette Syndrome: Functional imaging of motor activation pathways in verbal and motor tics
Principal Investigator: Mostofsky, Stewart
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Motor skill learning in autism: assessment and treatment of altered patterns of learning.
Principal Investigator: Mostofsky, Stewart
Detailed study of motor impairments in autism can provide valuable insights into the neural basis of the disorder and help to guide its treatment. Given the developmental nature of autism, during the...
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Motor Skill Learning in Autism
Principal Investigator: Mostofsky, Stewart
Abnormalities on motor examination have often afforded valuable insights into developmental disorders of the brain; such abnormalities have been well documented in individuals with autism and, in...
View Abstract
Pathogenesis of Rett Syndrome
Principal Investigator: Naidu, SakkuBai
This is an observational study of the natural history and clinical course of Rett Syndrome (RTT), a neurodevelopmental disorder primarily affecting females, caused by mutations in the MeCP2 gene. Our...
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KKI Weblink for researchers in Rett Syndrome
Principal Investigator: Naidu, SakkuBai
Creation of a Weblink for Researchers in Rett syndrome to request de-identified data from clinical evaluations collected on our patients with Rett syndrome (RTT) in The Natural History study "...
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Dextromethorphan in Rett syndrome
Principal Investigator: Naidu, SakkuBai
Dr. SakkuBai Naidu of the Kennedy Krieger Institute is initiating a clinical drug trial using dextromethorphan (DM) in Rett Syndrome (RTT) at the Pediatric Clinical Research Unit (PCRU) of the Johns...
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Placebo-Controlled Trial of Dextromethorphan in Rett Syndrome
Principal Investigator: Naidu, SakkuBai
The overall goal of this study is to counter the effects of increased N-methyl-D-aspartate (NMDA)/glutamate receptors in MeCP2-mutation-positive Rett syndrome (RTT) subjects by use of a placebo-...
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Physical, Functional and Neurological Effects of Two Lower Extremity Exercise Protocols in Children with Cerebral Palsy
Principal Investigator: Pekar, James
The primary site for this study is the National Institutes of Health Clinical Center with Dr. Diane Damiano as the principal investigator. All study participants will be consented and enrolled at the...
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Chromosomal abnormalities underlying developmental disabilities
Principal Investigator: Pevsner, Jonathan
The research question we would like to address is whether children with developmental disabilities have identifiable chromosomal abnormalities. The approach is in four parts:(1) prescreen and recruit...
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Pediatric Constraint-Induced Movement Therapy for Children with Hemiparesis: Outcomes of a Clinical Model
Principal Investigator: Pidcock, Frank
Does the function of children with hemiparesis improve after treatment involving constraint of the less impaired upper extremity in conjunction with intensive therapies? We will investigate this...
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Outpatient Research Registry
Principal Investigator: Pritchard, Alison
The primary objective of this protocol is to gather information on Neuropsychology outpatients that can later be accessed for screening purposes (to determine eligibility for research studies...
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Effect of glycerol trierucate on clinical course of Adrenoleukodystrophy
Principal Investigator: Raymond, Gerald
Adrenoleukodystrophy is a disorder of very long chain fatty acids secondary to defects in peroxisomal beta oxidation. The accumulation of these fatty acids results in a disorder of the adrenal glands...
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Compassionate usage of Lorenzo's Oil in peroxisomal disorders
Principal Investigator: Raymond, Gerald
Lorenzo's oil, a mixture of glyceryl trioleate and glyceryl trierucate, lowers very long chain fatty acids in X-linked adrenoleukodystrophy. There is preliminary data that lowering very long chain...
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Newborn Screening for X-Linked Adrenoleukodystrophy and Other Peroxisomal Disorders
Principal Investigator: Raymond, Gerald
Adrenoleukodystropy is an X-linked disorder that has variable manifestations including adrenal insufficiency, inflammatory demyelination of the brain, and in adults, a progressive spastic paraparesis...
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Nutrition Survey of Individuals with Rhizomelic Chondrodysplasia Punctata (RCDP) and Other Disorders of Plasmalogen Biosynthesis
Principal Investigator: Raymond, Gerald
Peroxisomal disorders of plasmalogen synthesis are rare, inborn errors of metabolism that can result in rhizomelic chondrodysplasia punctata (RCDP). RCDP has been presumed to be clinically severe,...
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Genetic Causes of Mental Retardation
Principal Investigator: Raymond, Gerald
The purpose of this study is to define the biochemical and genetic basis of peroxisomal disorders and to develop new methods for prevention and treatment. The study obtains samples of blood or skin...
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A Retrospective Study to Characterize the Natural History of Childhood Cerebral X-Linked Adrenoleukodystrophy and to Investigate the Influence of Allogeneic Transplantation on Affected Subjects
Principal Investigator: Raymond, Gerald
This is a retrospective study designed to: Collect specific and sufficient data necessary to characterize the natural history of disease in subjects with untreated childhood cerebral ALD To collect...
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Virtual Sailing Simulator in Individuals with Spinal Cord Injury
Principal Investigator: Recio, Albert
The benefits of sport and recreational activities for the disabled are well recognized from the standpoint of health and quality of life. Yet there remains a lack of options for most disabled people...
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Developmental Outcomes in Children with Unilateral and Mild/Moderate Hearing Loss
Principal Investigator: Reesman, Jennifer
The primary goal of the present study is to begin to develop a program of research to capture developmental outcomes in children with hearing loss, with a current focus on unilateral (UL) and mild/...
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Relation of Severity of injury with Testosterone profile & osteoporosis in spinal cord injured men
Principal Investigator: Sadowsky, Cristina
Hypothesis: Higher spinal cord injury neurologic level correlates with decreased testosterone level and increased prevalence of secondary osteoporosis.  Spinal cord injury is more common in...
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Incidence of Osteoporosis in Patients with Chronic Spinal Cord Dysfunction
Principal Investigator: Sadowsky, Cristina
Research Question: Prevalence of osteoporosis in patients with traumatic and non-traumatic spinal cord injury. Secondary Question: Relationship between bone mass, injury level and grade (ASIA), total...
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