Sponsored by Eli Lilly and Company, the primary aim of this study is to assess whether an increase in BMD will result from the use of rhPTH. Furthermore, PTH has been shown to have effects on bone...
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Funded Research Projects
The IBMD-OI Study: A Study to Assess the Effectiveness of Teriparatide (FORTEO)
Principal Investigator: Shapiro, Jay
Treatment of Osteoporosis in Murine Rett Syndrome Models
Principal Investigator: Shapiro, Jay
Sponsored by the International Rett Syndrome Foundation.
At the Kennedy Krieger Institute, approximately 50 percent of young children and adults with Rett syndrome (RTT) have osteoporosis; 11 percent...
Nutrition and Its Impact on Bone Growth in Children with Osteogenesis Imperfecta
Principal Investigator: Shapiro, Jay
Sponsored by the Edward & Stella Van Houten Memorial Fund
To provide information that may directly translate into improved care for children with OI and open the subject of nutrition as related...
Treatment of Osteoporosis in Murine Rett Syndrome Models: Comparison of Zoledronic Acid vs. Teriparatide on Osteoblast Function, Gene Expression and Bone Mass
Principal Investigator: Shapiro, Jay
This project developed from my practice of seeing patients with Rett Syndrome (RTT) and bone abnormalities at the Kennedy Krieger Institute. The recognition of osteoporosis and the resulting...
Aging and Dementia in Adults with Down Syndrome
Principal Investigator: Silverman, Wayne
This ongoing NIH supported Program Project will be renewed for another five years, and is programmatically a seamless continuation of my current Exempt protocol (#NA_00002225; "Changes in Functioning...
Cystic Fibrosis Nutritional Education and Behavioral Training: A Clinic
Principal Investigator: Slifer, Keith
The purpose of this pilot study is to examine the feasibility and potential benefits of a clinic-based collaborative behavioral and nutrition intervention that targets improvements in BMI percentile...
The Reliability and Validity of the CPCHILD in Children with Holoprosencephaly (HPE) or a Related Brain Malformation
Principal Investigator: Stashinko, Elaine
Children with holoprosencephaly (HPE) and severe brain malformations undergo expensive treatments to improve their health and quality of life, yet there are no valid and reliable measures to assess...
Drug Discovery for AMN
Principal Investigator: Steinberg, Steven
The overall goal is to accelerate the pace at which new therapies for the most common inherited peroxisomal disorder, adrenomyeloneuropathy (AMN), are discovered and tested in clinical trials through...
Drug Discovery for AMN
Principal Investigator: Steinberg, Steven
Sponsored by the Korengold AMN Research Fund.
The overall goal of this research project is to accelerate the pace at which new therapies for the most common inherited peroxisomal disorder,...
Neural Basis of Recovery of Inhibitory Control After Pediatric TBI
Principal Investigator: Suskauer, Stacy
Sponsored by NIH/NICHD - 5 K23 HD061611
Inhibitory control is frequently impaired following pediatric traumatic brain injury (TBI), and deficits in inhibitory control impact a child's function in...
Biomarkers of mild traumatic brain injury in children: predicting outcome and understanding recovery
Principal Investigator: Suskauer, Stacey
Scientific Abstract: Current management of childhood mild TBI (mTBI, also known as concussion) is symptombased. Symptoms may last from hours to years, yet we lack objective biomarkers with which to...
Double Masked Placebo Controlled Trial of Cholesterol in Hypocholesterolemic ASD
Principal Investigator: Tierney, Elaine
We have performed pilot work suggesting that some individuals with autism spectrum disorders (ASD) have very low blood cholesterol levels. This low cholesterol and other conditions with low sterols (...
Double-Masked Placebo-Controlled Trial of Cholesterol in Hypocholesterolemic ASD
Principal Investigator: Tierney, Elaine
Sponsored by Autism Speaks -- Grant #2990
Previous work from the Tierney laboratory has suggested that some individuals with autism spectrum disorders (ASD) have very low blood cholesterol levels....
11.7T Horizontal Bore Animal Scanner
Principal Investigator: Van Zijl, Peter
We propose to purchase an 11.7T animal research Magnetic resonance imaging (MRI) and spectroscopy (MRS) scanner for the F.M. Kirby Research Center at Kennedy Krieger Institute (KKI). This scanner...
Annual Meeting of the NCRR/NIBIB Principal Investigators
Principal Investigator: Van Zijl, Peter
We propose to continue the annual meetings of the Directors and Assistant Directors of the NCRR and NIBIB P41 Centers. The 2 1/2 day meeting is held annually in late June in Bethesda, Maryland. The...
Radiofrequency Transmit and Revieve Upgrade for 3T Research Scanner
Principal Investigator: Van Zijl, Peter
We propose to upgrade the radiofrequency (RF) capabilities of our 3T research scanner at the F.M. Kirby Research Center of the Hugo Moser Research Institute at Kennedy Krieger (KKI). The purpose is...
Resource for Quantitative Functional MRI
Principal Investigator: Van Zijl, Peter
The Resource for Quantitative Functional Magnetic Resonance Imaging is an interdepartmental and interdisciplinary laboratory combining facilities of the F.M. Kirby Research Center for Functional...
Novel Approaches for CEST Labeling, Detection, Quantification, and Translation
Principal Investigator: Van Zijl, Peter
The overall Program Project focuses on the design and detection of bioorganic biodegradable Chemical Exchange Saturation Transfer (CEST) agents, with the ultimate goal of their practical application...
Cognitive Correlates of Childhood Anxiety Disorders
Principal Investigator: Vasa, Roma
This K23 proposal is a 5-year plan to develop the candidate, a child psychiatrist, into an independent researcher investigating the cognitive underpinnings of childhood anxiety disorders. The long-...
Magnetic Resonance Spectroscopy Imaging as a Biomarker for FSHD
Principal Investigator: Wagner, Kathryn
Sponsored by the American Academy of Neurology -- 2011 AAN Clinical Research Training Fellowship.
Recent advances in the study of heritable neuromuscular disorders have led to multiple promising...
A Novel Xenograft Mouse Model of Facioscapulohumeral Muscular Dystrophy
Principal Investigator: Wagner, Kathryn
Despite being one of the most prevalent neuromuscular disorders worldwide, there have been very few clinical trials in Facioscapulohumeral muscular dystrophy (FSHD). Currently there are no clinical...
Acyl-CoA Synthetase ACSVL3 in Malignant Glioma: Metabolism and Oncogenic Cellular
Principal Investigator: Watkins, Paul
Malignant glioma accounts for a significant percentage of brain tumors. As these tumors are typically refractory to treatment, there is a need for new and novel therapeutic approaches. Levels of...
Role of ACSBG1 in the Biochemical Pathology of X-Linked Adrenoleukodystrophy (X-ALD)
Principal Investigator: Watkins, Paul
X-linked adrenoleukodystrophy (X-ALD) is a severe, progressive neurodegenerative disorder characterized by central demyelination (cerebral form) or distal axonopathy (spinal cord form). Adrenal...
Development of a High Throughput Essay for Inhibitor of ACSVL3, a Therapeutic Target in Malignant Glioma
Principal Investigator: Watkins, Paul
Gliomas account for more than half of brain tumors, and nearly two-thirds of gliomas are highly aggressive glioblastomas. Despite recent therapeutic advances, glioblastoma carries a very poor...
Understanding Mechanisms of Lower Extremity Strengthening in Women Heterozygous for X-ALD
Principal Investigator: Zackowski, Kathleen
Sponsored by the ELA Foundation.
X-linked adrenoleukodystrophy (X-ALD), a sex-linked progressive neurodegenerative disease, is caused by a defect in the ABCD1 gene. The disease is expressed in...
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