We recently made the surprising discovery that mitochondria from retinal ganglion cell axons are passed onto neighboring astrocytes for degradation in the optic nerve head of normal mice. We present...
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Funded Research Projects
Transcellular Degradation of Mitochondria in the Central Nervous System
Principal Investigator: Marsh-Armstrong, Nicholas
Relationship of MRI to ASIA Impairment Scale in Chronic Spinal Cord Injury
Principal Investigator: McDonald, John
Development of imaging correlates of the integrity of spinal cord white matter is needed for optimizing design of clinical trials in spinal cord injury and therapies for patients with chronic spinal...
Advanced Restoration Therapies in Spinal Cord Injury 0186 - FY 08 - 09
Principal Investigator: McDonald, John
Evidence suggests that functional electrical stimulation (FES) can improve certain functions in the central nervous system (CNS) following injury or disease. Using FES-based therapies in spinal cord...
Advanced Restoration Therapies in Spinal Cord Injury 0192 – FY07
Principal Investigator: McDonald, John
Recent evidence suggests that functional electrical stimulation (FES) can improve certain functions in the CNS following injury or disease. Our preliminary clinical observations utilizing FES...
Localized Growth Factors Effects on Myelination by hESC Derived Oligodendrocytes in a Novel Microfluidic Platform
Principal Investigator: McDonald, John
In the central nervous system (CNS), the loss of protective myelin sheath surrounding axons, known as demyelination, is a major cause of sensory and motor function deficits in diseases such as...
Developing New Multicolor Polypeptide MR Contrast Agents for Stem Cell Tracking
Principal Investigator: McMahon, Michael
Development of new contrast materials is important to expand the diagnostic capabilities of MR at the cellular and molecular level. In particular, providing information on cell migration, trafficking...
16.4T Vertical Wide Bore Animal MR Imager
Principal Investigator: McMahon, Michael
We propose to acquire a 16.4 Tesla wide-bore vertical magnetic resonance (MR) small- animal scanner equipped with multi-coil receive capability. The overall goal is to upgrade the F.M. Kirby Research...
Multi-Color Exchange Transfer Imaging of Drug Delivery Nanocarriers
Principal Investigator: McMahon, Michael
This project focuses on the design of biodegradable contrast agents, based on peptides and heterocycles, to be used for the labeling of drug delivery vehicles such as liposomes and polymeric...
OIACEST Islet Cell Capsules for Immunoprotection, MR Detection, and pH Sending
Principal Investigator: McMahon, Michael
Good glycemic control is critical in reducing the end-stage complications of Type I Diabetes Mellitus (TIDM) and, for this reason, islet transplantation (ITx) has received considerable attention in...
Novel Approaches for Investigating the Neurology of Autism: Detailed Morphometric Analysis and Correlation with Motor Impairment
Principal Investigator: Mostofsky, Stewart
In order to understand how to best diagnose and treat individuals with autism, it is important to identify the brain abnormalities associated with the disorder. Studies of postmortem brain tissue...
Anomalus Motor Physiology in ADHD
Principal Investigator: Mostofsky, Stewart
The hypothesis of this study is that the neuromotor anomalies present in children with ADHD will be associated with deficient intracortical and interhemispheric inhibition of the motor cortex. This...
Neurology of Deficient Response Control in ADHD
Principal Investigator: Mostofsky, Stewart
Building on evidence established in the initial grant period, the overall goals of the proposed study, “Neurology of Deficient Response Control in ADHD,” are to apply advanced neuroimaging and...
Motor Skill Learning in Autism
Principal Investigator: Mostofsky, Stewart
Abnormalities on motor examination have often afforded valuable insights into developmental disorders of the brain; such abnormalities have been well documented in individuals with autism and, in...
Tourette Syndrome Association Neuroimaging Consortium Pilot Study
Principal Investigator: Mostofsky, Stewart
Sponsored by TSA-WU-12-91.
Important research on Tourette Syndrome (TS) is proceeding along several fronts, from gene-hunting to controlled trials of new treatments. The TSA has fostered...
Pathogenesis of Rett Syndrome
Principal Investigator: Naidu, SakkuBai
This is an observational study of the natural history and clinical course of Rett Syndrome (RTT), a neurodevelopmental disorder primarily affecting females, caused by mutations in the MeCP2 gene. Our...
Placebo-Controlled Trial of Dextromethorphan in Rett Syndrome
Principal Investigator: Naidu, SakkuBai
The overall goal of this study is to counter the effects of increased N-methyl-D-aspartate (NMDA)/glutamate receptors in MeCP2-mutation-positive Rett syndrome (RTT) subjects by use of a placebo-...
Understanding the Brain Basis of Impaired Imitation Learning in Autism
Principal Investigator: Nebel, Mary Beth
In a developmental disorder such as autism (ASD), brain-based learning mechanisms vital to the acquisition of motor skills may contribute to impaired development of social and communicative abilities...
The Role of the Transcallosal Pathway in Neuroplasticity Following Nerve Injury
Principal Investigator: Pelled, Galit
Peripheral nerve injury causes sensory dysfunctions that are thought to be attributable not only to the functional, cellular and biochemical events occurring in the peripheral nerve, but also to the...
Adaptive Control of Epileptic Seizures Using A Genetically Encoded Sensor
Principal Investigator: Pelled, Galit
Sponsored by the National Institutes of Health (NIH) -- 1R01NS079288-01.
About 35 percent of epileptic patients do not respond to antiepileptic drugs. Of these, only a quarter of them can be treated...
Long-term plasticity and recovery in pediatric TBI rat model
Principal Investigator: Pelled, Galit
Abstract: Traumatic brain injury (TBI) is a leading concern in children and young adults in the United States, with more than 3,000 deaths and 29,000 hospitalizations annually (Centers for Disease...
Accommodations for ADHD: Are They Effective in Reducing the Impact of the Disorder?
Principal Investigator: Pritchard, Alison
One of the most important functions served by a pediatric neuropsychological assessment is the provision of evidence-based recommendations and resources designed to reduce symptoms and improve...
Pediatric Psychology and Neuropsychology Predoctoral Internship Training - Abstract
Principal Investigator: Reesman, Jennifer
Hearing loss or deafness affects more than 48.1 million individuals in the United States, with nearly 1 in 5 Americans displaying a hearing loss as defined by the World Health Organization criteria (...
Life in Motion Wellness Program
Principal Investigator: Sachs, Christy
The benefits of sport and recreational activities for individuals with disabilities are well recognized from the standpoint of health and quality of life, yet there remains a lack of options. Kennedy...
ArmAware: A Novel Device to Treat Motor Disorders
Principal Investigator: Salorio, Cynthia
The goal of this project is to develop a prototype of a novel device to treat hemiplegia. The award covers development costs of the initial prototypes.
Kennedy Krieger Institute's Linked Clinical Research Center in Osteogenesis Imperfecta
Principal Investigator: Shapiro, Jay
As a participant of the Linked Clinical Research Centers (LCRC), the Osteogenesis Imperfecta (or) Program at the Kennedy Krieger Institute (KKI) brings an established record of multidiscliplinary...
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