Perinatal hypoxic-ischemic brain injuries are an important cause of cerebral palsy. To understand the mechanisms for these brain injuries and develop neuroprotective strategies, we use rodent models...
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Funded Research Projects
Neurotransmitter Injury Mechanisms in Developing Brain
Principal Investigator: Johnston, Michael
Research Training in Rehabilitation for Brain Injury and Neurological Disability
Principal Investigator: Johnston, Michael
This is the first resubmission of an application for renewal of an Institutional National Research Service Award for a successful postdoctoral training program in medical rehabilitation research that...
A Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy, Safety, and Tolerability of STX209 (Arbaclofen) Administered for the Treatment of Social Withdrawal in Adolescents and Adults with Fragile X Syndrome
Principal Investigator: Johnston, Michael
The objective of this study is to explore the efficacy, safety, and tolerability of STX209 (arbaclofen) administered for the treatment of social withdrawal in subjects with Fragile X Syndrome (FXS)....
The Impact of Nap Restriction on Napping in Preschoolers
Principal Investigator: Lam, Janet
Sponsored by the Thomas Wilson Foundation -- 6304.
Preschools and daycare centers have increasingly reduced napping in early childhood programs. Because young children have an increased diurnal sleep...
Multisite RCT of Early Intervention for Spoken Communication in Autism
Principal Investigator: Landa, Rebecca
While significant progress has been made toward identifying effective interventions for preschool-age children with autism (National Research Council, 2001), few scientifically rigorous studies have...
Autism: Social and Communication Predictors in Siblings
Principal Investigator: Landa, Rebecca
This is a longitudinal study of Autism Spectrum Disorders (ASD). Six groups will be assessed longitudinally. Group 1: siblings of probands with autism; (Group 2) late talkers having no family history...
MCH Research - Parent-Mediated Vs. Center-Based Intervention for Toddlers with ASD: An RCT
Principal Investigator: Landa, Rebecca
An ever increasing number of toddlers are identified as being at high risk for ASD. This translates into an increasing demand for Part C Early Intervention services. The importance of intervention...
Autism Treatment Network (ATN)
Principal Investigator: Landa, Rebecca
The Center for Autism and Related Disorders (CARD) at Kennedy Krieger Institute (KKI) is a multi-faceted, multidisciplinary program for children with autism spectrum disorders (ASD) and their family...
Effects of Self-Generated Experiences on Social Cognitive Development in Young Children with Autism
Principal Investigator: Landa, Rebecca
Sponsored by Autism Speaks -- 7746.
This study will test whether a novel treatment for social impairment in young children with autism spectrum disorders (ASD) leads to improvement at behavioral and...
Mechanisms of Chemo/Radioresistance in Human Gliomas
Principal Investigator: Laterra, John
Malignant glioma ranks among the least curable of human cancer despite aggressive surgery, radiation therapy, chemotherapy, and the emergence of new targeted molecular therapeutics. This...
Molecular Mechanisms of Tumor-Propagation by Human Glioblastoma Stem Cells
Principal Investigator: Laterra, John
Glioblastoma multiforme (GBM) is the most common and most aggressive brain cancer. Survival for patients with GBM remains dismal. Half of the patients survival for less than 14 months and few live...
Neutralizing Anti-HGF mAbs and CNS Malignancy
Principal Investigator: Laterra, John
Malignant progression and poor survival in glioma and many other solid malignancies are linked with over-expression of the transmembraneous receptor tyrosine kinase c-Met and its secreted ligand...
Regulatory Mechanisms and Therapeutic Targeting of Brain Cancer "Stem Cells"
Principal Investigator: Laterra, John
During the past decade, there has been a re-emergence of the concept that cancers harbor small populations of malignant stem-like cells (often referred to as cancer stem cells) that sustain tumor...
Suppression of Glioblastoma Stem Cells by Kruppel-Like Factor 9
Principal Investigator: Laterra, John
Glioblastoma stem-like cells (or cancer stem cells, CSCs) maintain a capacity for multi-lineage differentiation and efficiently propagate tumor xenografts that accurately recapitulate the complex...
Regulation of Neural and Neoplastic Stem Cells by Kruppel-like Transcription Factors
Principal Investigator: Laterra, John
Sponsored by the Maryland Stem Cell Research Fund: 2011-MSCRFII-0073-00.
The effective application of stem cell (SC)-based therapeutics for disorders of the central nervous system require the...
Accelerating Autism Research
Principal Investigator: Law, Paul
The proposed project will enable the Interactive Autism Network (IAN) to provide recruitment assistance to qualified research projects throughout the U.S. and to provide a large, validated...
Interactive Autism Network Project
Principal Investigator: Law, Paul
The Interactive Autism Network (IAN) was established in 2006 to accelerate autism spectrum disorder (ASD) related research by creating a national online registry and longitudinal research...
Assessing the Accuracy of Rapid Phenotyping of Nonverbal Autistic Children
Principal Investigator: Law, Paul
Sponsored by Autism Speaks -- 7566.
Autism spectrum disorders (ASD) are extremely heterogeneous, presenting with a wide range of phenotypic characteristics. High twin concordance and increased...
Neuroimaging, Behavior, and Biochemical Correlates in Smith-Lemli-Opitz Syndrome (SLOS)
Principal Investigator: Lee, Ryan
SLOS is an autosomal recessive, multiple malformation syndrome of impaired cholesterol biosynthesis resulting in decreased cholesterol and elevated concentrations of abnormal sterols in tissues and...
Monitoring Prodrug Delivery in Suicide Gene Therapy Using CEST MRI
Principal Investigator: Liu, Guanshu
To accelerate the development of nanotechnologies for drug and gene delivery, it is highly desired to construct nanoparticles with imaging capabilities so that the process of delivery and release can...
Frontostriatal Glutamate in ADHD: Neuropsychological and Behavioral Correlates
Principal Investigator: Mahone, E. Mark
Sponsored by the National Institutes of Health -- R21MH092693-01.
The overall goal of the proposed investigation, "Frontostriatal Glutamate in ADHD: Neuropsychological and Behavioral Correlates" is...
The Incremental Validity of Neuropsychological Assessment in the Identification of and Treatment of ADHD
Principal Investigator: Mahone, E. Mark
Sponsored by the American Academy of Clinical Neuropsychology (AACN).
The principles of evidence-based practice have increasingly been recognized by patients, clinicians and third-party payors as...
Catalyst for a Cure Research Consortium of the Glaucoma Research Foundation
Principal Investigator: Marsh-Armstrong, Nicholas
The long term goal of these studies is to uncover cellular and molecular mechanisms that underlie why retinal ganglion cells (RGCs) die in glaucoma. Glaucoma is a blinding disease that affects over...
Role of a Novel Corepressor in Nuclear Receptor Action
Principal Investigator: Marsh-Armstrong, Nicholas
The long term goal of this work is to understand how gene regulatory networks controlled by hormones regulate developmental and physiological processes. Nuclear receptors mediate the actions of a...
Optic Nerve Head Synucleinopathy in Glaucoma and Function of Gamma-Synuclein
Principal Investigator: Marsh-Armstrong, Nicholas
The broad long-term goal of this application is to uncover the mechanism of retinal ganglion cell (RGC) degeneration in glaucoma so as to be able to design rational therapeutic interventions based on...
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