Funded Research Projects

Pediatric Psychology and Neuropsychology Predoctoral Internship Training - Abstract
Principal Investigator: Reesman, Jennifer
Hearing loss or deafness affects more than 48.1 million individuals in the United States, with nearly 1 in 5 Americans displaying a hearing loss as defined by the World Health Organization criteria (...
Delay Discounting in Children with ADHD: Neuroimaging and Behavioral Correlates
Principal Investigator: Rosch, Keri Shiels
My long-term career goal is to establish a research program to improve treatments for ADHD, with an emphasis on doing so through improved understanding of alterations in cognition and motivation in...
ArmAware: A Novel Device to Treat Motor Disorders
Principal Investigator: Salorio, Cynthia
The goal of this project is to develop a prototype of a novel device to treat hemiplegia. The award covers development costs of the initial prototypes.
Characterization of Biochemical Abnormalities Underlying Mitochondrial Dysfunction and Cardiomyopathy in Barth Syndrome and Adenine Nucleotide Translocase 1 (ANT-1) Deficiency
Principal Investigator: Sandlers, Yana
The treatment of many inborn errors of metabolism is centered on recognizing and correcting, or compensating for metabolic aberrations. The limited understanding of the complexity of the biochemical...
Kennedy Krieger Institute's Linked Clinical Research Center in Osteogenesis Imperfecta
Principal Investigator: Shapiro, Jay
As a participant of the Linked Clinical Research Centers (LCRC), the Osteogenesis Imperfecta (or) Program at the Kennedy Krieger Institute (KKI) brings an established record of multidiscliplinary...
The IBMD-OI Study: A Study to Assess the Effectiveness of Teriparatide (FORTEO)
Principal Investigator: Shapiro, Jay
Sponsored by Eli Lilly and Company, the primary aim of this study is to assess whether an increase in BMD will result from the use of rhPTH. Furthermore, PTH has been shown to have effects on bone...
Treatment of Osteoporosis in Murine Rett Syndrome Models
Principal Investigator: Shapiro, Jay
Sponsored by the International Rett Syndrome Foundation. At the Kennedy Krieger Institute, approximately 50 percent of young children and adults with Rett syndrome (RTT) have osteoporosis; 11 percent...
Nutrition and Its Impact on Bone Growth in Children with Osteogenesis Imperfecta
Principal Investigator: Shapiro, Jay
Sponsored by the Edward & Stella Van Houten Memorial Fund To provide information that may directly translate into improved care for children with OI and open the subject of nutrition as related...
Treatment of Osteoporosis in Murine Rett Syndrome Models: Comparison of Zoledronic Acid vs. Teriparatide on Osteoblast Function, Gene Expression and Bone Mass
Principal Investigator: Shapiro, Jay
This project developed from my practice of seeing patients with Rett Syndrome (RTT) and bone abnormalities at the Kennedy Krieger Institute.  The recognition of osteoporosis and the resulting...
Aging and Dementia in Adults with Down Syndrome
Principal Investigator: Silverman, Wayne
This ongoing NIH supported Program Project will be renewed for another five years, and is programmatically a seamless continuation of my current Exempt protocol (#NA_00002225; "Changes in Functioning...
Drug Discovery for AMN
Principal Investigator: Steinberg, Steven
The overall goal is to accelerate the pace at which new therapies for the most common inherited peroxisomal disorder, adrenomyeloneuropathy (AMN), are discovered and tested in clinical trials through...
Pilot Treatment of the PEX1-G844D Mouse with Diosmetin
Principal Investigator: Steinberg, Steven
We created the Pex1-G844D mouse to model the clinical phenotype found in humans associated with homozygosity for the equivalent PEX1 mutation, PEX1-G843D.   The Pex1-G844D mouse model...
Neural Basis of Recovery of Inhibitory Control After Pediatric TBI
Principal Investigator: Suskauer, Stacy
Sponsored by NIH/NICHD - 5 K23 HD061611 Inhibitory control is frequently impaired following pediatric traumatic brain injury (TBI), and deficits in inhibitory control impact a child's function in...
Biomarkers of mild traumatic brain injury in children: predicting outcome and understanding recovery
Principal Investigator: Suskauer, Stacey
Scientific Abstract: Current management of childhood mild TBI (mTBI, also known as concussion) is symptombased. Symptoms may last from hours to years, yet we lack objective biomarkers with which to...
Somatosensory Processing-Assessing Youth Sports-Related Concussion and Recovery
Principal Investigator: Suskauer, Stacy
Youth sports-related concussion (SRC) is a public health problem in the United States, as evidenced by the public health approach of youth concussion laws which are now in effect in more than 40...
Annual Meeting of the NCRR/NIBIB Principal Investigators
Principal Investigator: Van Zijl, Peter
We propose to continue the annual meetings of the Directors and Assistant Directors of the NCRR and NIBIB P41 Centers. The 2 1/2 day meeting is held annually in late June in Bethesda, Maryland. The...
Resource for Quantitative Functional MRI
Principal Investigator: Van Zijl, Peter
The Resource for Quantitative Functional Magnetic Resonance Imaging is an interdepartmental and interdisciplinary laboratory combining facilities of the F.M. Kirby Research Center for Functional...
Novel Approaches for CEST Labeling, Detection, Quantification, and Translation
Principal Investigator: Van Zijl, Peter
The overall Program Project focuses on the design and detection of bioorganic biodegradable Chemical Exchange Saturation Transfer (CEST) agents, with the ultimate goal of their practical application...
Magnetic Resonance Spectroscopy Imaging as a Biomarker for FSHD
Principal Investigator: Wagner, Kathryn
Sponsored by the American Academy of Neurology -- 2011 AAN Clinical Research Training Fellowship. Recent advances in the study of heritable neuromuscular disorders have led to multiple promising...
A Novel Xenograft Mouse Model of Facioscapulohumeral Muscular Dystrophy
Principal Investigator: Wagner, Kathryn
Despite being one of the most prevalent neuromuscular disorders worldwide, there have been very few clinical trials in Facioscapulohumeral muscular dystrophy (FSHD). Currently there are no clinical...
Biomarkers of Facioscapulohumeral Muscular Dystrophy (FSHD)
Principal Investigator: Wagner, Kathryn
This NIH-funded study is established to identify biomarkers for facioscapulohumeral muscular dystrophy (FSHD). FSHD patients and their unaffected first degree relative will undergo open muscle biopsy...
Duchenne Muscular Dystrophy: Double-Blind Randomized Trial to Find The Optimum Steroid Regimen (FOR-DMD)
Principal Investigator: Wagner, Kathryn
This Phase III multi-center, double-blind, parallel group, 36 - 60 month study funded by the NIH will compare three corticosteroid regimens in wide use in DMD: 1) daily prednisone (0.75 mg/kg/day); 2...
Magnetic Resonance Imaging and Spectroscopy Biomarkers for Facioscapulohumeral Muscular Dystrophy
Principal Investigator: Wagner, Kathryn
This study, supported by the FSH Society, will utilize magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) to develop non-invasive, quantitative imaging biomarkers for...
HALO-DMD-01: A Phase 1b Open Label, Single and Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics (PK) of HT-100 in Patients with Duchenne Muscular Dystrophy
Principal Investigator: Wagner, Kathryn
The study, sponsored by HALO Therapeutics, is designed to provide initial safety, tolerability, and PK data of halofuginone hydrobromide, HT-100, in young boys ages 6-20 years with DMD.  HT-100...
HALO-DMD-02: An Open Label Extension Study of HT-100 in Patients with Duchenne Muscular Dystrophy who have Completed Protocol HALO-DMD-01
Principal Investigator: Wagner, Kathryn
This open-label, multiple dose extension study is designed to evaluate the safety, tolerability, pharmacodynamic signals, and population PK of HT-100, a delayed-release, orally-delivered agent in...