Funded Research Projects

Accelerating Autism Research
Principal Investigator: Law, Paul
The proposed project will enable the Interactive Autism Network (IAN) to provide recruitment assistance to qualified research projects throughout the U.S. and to provide a large, validated...
Neuroimaging, Behavior, and Biochemical Correlates in Smith-Lemli-Opitz Syndrome (SLOS)
Principal Investigator: Lee, Ryan
SLOS is an autosomal recessive, multiple malformation syndrome of impaired cholesterol biosynthesis resulting in decreased cholesterol and elevated concentrations of abnormal sterols in tissues and...
Interactive Autism Network Project
Principal Investigator: Lipkin, Paul
The Interactive Autism Network (IAN) was established in 2006 to accelerate autism spectrum disorder (ASD) related research by creating a national online registry and longitudinal research...
Monitoring Prodrug Delivery in Suicide Gene Therapy Using CEST MRI
Principal Investigator: Liu, Guanshu
To accelerate the development of nanotechnologies for drug and gene delivery, it is highly desired to construct nanoparticles with imaging capabilities so that the process of delivery and release can...
Optic Nerve Head Synucleinopathy in Glaucoma and Function of Gamma-Synuclein
Principal Investigator: Marsh-Armstrong, Nicholas
The broad long-term goal of this application is to uncover the mechanism of retinal ganglion cell (RGC) degeneration in glaucoma so as to be able to design rational therapeutic interventions based on...
Transcellular Degradation of Mitochondria in the Central Nervous System
Principal Investigator: Marsh-Armstrong, Nicholas
We recently made the surprising discovery that mitochondria from retinal ganglion cell axons are passed onto neighboring astrocytes for degradation in the optic nerve head of normal mice. We present...
Advanced Restoration Therapies in Spinal Cord Injury 0186 - FY 08 - 09
Principal Investigator: McDonald, John
Evidence suggests that functional electrical stimulation (FES) can improve certain functions in the central nervous system (CNS) following injury or disease. Using FES-based therapies in spinal cord...
Developing New Multicolor Polypeptide MR Contrast Agents for Stem Cell Tracking
Principal Investigator: McMahon, Michael
Development of new contrast materials is important to expand the diagnostic capabilities of MR at the cellular and molecular level. In particular, providing information on cell migration, trafficking...
Multi-Color Exchange Transfer Imaging of Drug Delivery Nanocarriers
Principal Investigator: McMahon, Michael
This project focuses on the design of biodegradable contrast agents, based on peptides and heterocycles, to be used for the labeling of drug delivery vehicles such as liposomes and polymeric...
OIACEST Islet Cell Capsules for Immunoprotection, MR Detection, and pH Sending
Principal Investigator: McMahon, Michael
Good glycemic control is critical in reducing the end-stage complications of Type I Diabetes Mellitus (TIDM) and, for this reason, islet transplantation (ITx) has received considerable attention in...
Anomalus Motor Physiology in ADHD
Principal Investigator: Mostofsky, Stewart
The hypothesis of this study is that the neuromotor anomalies present in children with ADHD will be associated with deficient intracortical and interhemispheric inhibition of the motor cortex. This...
Neurology of Deficient Response Control in ADHD
Principal Investigator: Mostofsky, Stewart
Building on evidence established in the initial grant period, the overall goals of the proposed study, “Neurology of Deficient Response Control in ADHD,” are to apply advanced neuroimaging and...
Motor Skill Learning in Autism
Principal Investigator: Mostofsky, Stewart
Abnormalities on motor examination have often afforded valuable insights into developmental disorders of the brain; such abnormalities have been well documented in individuals with autism and, in...
Pathogenesis of Rett Syndrome
Principal Investigator: Naidu, SakkuBai
This is an observational study of the natural history and clinical course of Rett Syndrome (RTT), a neurodevelopmental disorder primarily affecting females, caused by mutations in the MeCP2 gene. Our...
Placebo-Controlled Trial of Dextromethorphan in Rett Syndrome
Principal Investigator: Naidu, SakkuBai
The overall goal of this study is to counter the effects of increased N-methyl-D-aspartate (NMDA)/glutamate receptors in MeCP2-mutation-positive Rett syndrome (RTT) subjects by use of a placebo-...
Understanding the Brain Basis of Impaired Imitation Learning in Autism
Principal Investigator: Nebel, Mary Beth
In a developmental disorder such as autism (ASD), brain-based learning mechanisms vital to the acquisition of motor skills may contribute to impaired development of social and communicative abilities...
The Role of the Transcallosal Pathway in Neuroplasticity Following Nerve Injury
Principal Investigator: Pelled, Galit
Peripheral nerve injury causes sensory dysfunctions that are thought to be attributable not only to the functional, cellular and biochemical events occurring in the peripheral nerve, but also to the...
Adaptive Control of Epileptic Seizures Using A Genetically Encoded Sensor
Principal Investigator: Pelled, Galit
Sponsored by the National Institutes of Health (NIH) -- 1R01NS079288-01. About 35 percent of epileptic patients do not respond to antiepileptic drugs. Of these, only a quarter of them can be treated...
Pediatric Psychology and Neuropsychology Predoctoral Internship Training - Abstract
Principal Investigator: Reesman, Jennifer
Hearing loss or deafness affects more than 48.1 million individuals in the United States, with nearly 1 in 5 Americans displaying a hearing loss as defined by the World Health Organization criteria (...
ArmAware: A Novel Device to Treat Motor Disorders
Principal Investigator: Salorio, Cynthia
The goal of this project is to develop a prototype of a novel device to treat hemiplegia. The award covers development costs of the initial prototypes.
Kennedy Krieger Institute's Linked Clinical Research Center in Osteogenesis Imperfecta
Principal Investigator: Shapiro, Jay
As a participant of the Linked Clinical Research Centers (LCRC), the Osteogenesis Imperfecta (or) Program at the Kennedy Krieger Institute (KKI) brings an established record of multidiscliplinary...
The IBMD-OI Study: A Study to Assess the Effectiveness of Teriparatide (FORTEO)
Principal Investigator: Shapiro, Jay
Sponsored by Eli Lilly and Company, the primary aim of this study is to assess whether an increase in BMD will result from the use of rhPTH. Furthermore, PTH has been shown to have effects on bone...
Treatment of Osteoporosis in Murine Rett Syndrome Models
Principal Investigator: Shapiro, Jay
Sponsored by the International Rett Syndrome Foundation. At the Kennedy Krieger Institute, approximately 50 percent of young children and adults with Rett syndrome (RTT) have osteoporosis; 11 percent...
Nutrition and Its Impact on Bone Growth in Children with Osteogenesis Imperfecta
Principal Investigator: Shapiro, Jay
Sponsored by the Edward & Stella Van Houten Memorial Fund To provide information that may directly translate into improved care for children with OI and open the subject of nutrition as related...
Treatment of Osteoporosis in Murine Rett Syndrome Models: Comparison of Zoledronic Acid vs. Teriparatide on Osteoblast Function, Gene Expression and Bone Mass
Principal Investigator: Shapiro, Jay
This project developed from my practice of seeing patients with Rett Syndrome (RTT) and bone abnormalities at the Kennedy Krieger Institute.  The recognition of osteoporosis and the resulting...