The long term objective of this research is to improve the phenotypic characterization of autism by delineating the relative function of the interval timing system (ITS) in these individuals. The ITS...
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Funded Research Projects
Time Perception and Timed Performance in Autism
Principal Investigator: Allman, Melissa
Mechanisms and Rehabilitation of Cerebellar Ataxia
Principal Investigator: Bastian, Amy
Sponsored by the National Institutes of Health -- 2R01HD040289.
Cerebellar damage disrupts movement coordination. Actions ranging from walking to reaching become inaccurate and difficult to control,...
Human Locomotor Plasticity in Health and Disease
Principal Investigator: Bastian, Amy
Sponsored by the National Institutes of Health -- 5R01HD048741-06.
Walking patterns can adapt on short timescales (minutes to hours) to temporary conditions, such as icy sidewalks. They can also...
Kennedy Krieger Family Center - Integrated Trauma Approaches
Principal Investigator: Belcher, Harolyn
The goals of the Kennedy Krieger Family Center Trauma Intervention Program (TIP) are to:
Evaluate the feasibility and effectiveness of evidence-based treatment protocols, endorsed by the National...
Maternal Child Health Careers/Research Initiatives -- Undergraduate Program
Principal Investigator: Belcher, Harolyn
Sponsored by DHHS/CDC -- 1U50MN000025.
Healthy People 2020 highlights the importance of eliminating health disparities and increasing the quality and years of healthy life free of preventable disease...
Differentiation of Fibroblast-Derived Induced Pluripotent Cells into Oligodendrocytes for Treatment of Neurological Disorders
Principal Investigator: Belegu, Visar
Spinal cord injury is a devastating condition, which imposes major individual and societal costs. The goal of our work is to promote functional recovery in patients following spinal cord injury by...
Cerebellar Function and Rehabilitative Strategies
Principal Investigator: Bhanpuri, Nasir
Cerebellar damage causes motor coordination deficits or 'ataxia'-movements are variable and inaccurate, despite normal strength. Why cerebellar damage leads to these deficits is not understood. One...
The Use of NF kappa B Inhibitors in Treating Rett Syndrome
Principal Investigator: Bressler, Joseph
Sponsored by the International Rett Syndrome Foundation HeArt Grant.
The overall objective of this research project is to determine the potential benefit of treating children with RTT with drugs that...
Autism Spectrum Disorder in Down Syndrome: A Model of Repetitive and Stereotypic Behavior for Idiopathic ASD
Principal Investigator: Capone, George
The proposed project will be an initial delineation of the distinctive and specific features of Down syndrome (DS) and co-morbid Autism Spectrum Disorder (DS+ASD). The primary focus is on the...
A 12 Week Double Blind Placebo Clinical Trial to Evaluate the Safety and Efficacy of Rivastigimine in Children with Down Syndrome
Principal Investigator: Capone, George
Individuals with Down syndrome (DS) exhibit a notable cholinergic deficiency by the 4th decade of life. It is unclear how early in life presynaptic cholinergic deterioration begins or how it evolves...
Prevention and Early Intervention for Juvenile Delinquency
Principal Investigator: Cataldo, Michael
The current proposal seeks to further the Kennedy Krieger Institute’s (KKI) prevention and early intervention services to children and families at risk for child abuse and neglect, placement...
Translational Analyses of Chronic Aberrant Behavior Across the Life Span
Principal Investigator: Cataldo, Michael
Behavior disorders, including aggression and self-injury, can cause considerable suffering for individuals with intellectual and developmental disabilities (IDD) and their care givers, as well as...
Anticonvulsants, Ischemic Seizures and Regeneration in the Immature Brain
Principal Investigator: Comi, Anne
Neonatal stroke affects one in 4000 term births and frequently results in cognitive impairments. Neonatal strokes present with seizures, and anticonvulsants (usually phenobarbital) are administered...
Behavioral Economics in MR/DD and Behavior Disorders
Principal Investigator: DeLeon, Iser
Assessments of severe behavior disorders of children with intellectual and developmental disabilities (IDD) have revealed that behavior problems are often maintained by their functional outcomes (or...
Reading Disability in Grades 3 - 8: Neurocognitive Fact
Principal Investigator: Denckla, Martha
The overarching goal of this Research Center is to examine the reading disabilities (RDs) present in children grades 3-8, including classification, identification, treatment, prevalence,...
EEG-Based Assessment of Functional Connectivity in Autism
Principal Investigator: Ewen, Joshua
Sponsored by the National Institutes of Health -- 1K23NS073626-01.
There are substantial data to suggest that altered cerebral connectivity is a key aspect of the neurobiology of autism. Nevertheless...
Glial Progenitor Cell Transplantation in Mice with PVL
Principal Investigator: Fatemi, S. Ali
Perinatally acquired white matter injury (PWMI), also referred to as Periventricular Leukomalacia (PVL) is the leading cause of neurologic morbidity in premature infants leading to cerebral palsy and...
Study of White Matter Development in a Rodent Model of Perinatal Brain Injury
Principal Investigator: Fatemi, S. Ali
This is a Mentored Clinical Scientist Research Career Development Award allowing Dr. Fatemi to develop a career as an independent investigator in the field of translational neuroscience research,...
Comprehensive Long-Term Evaluation of the Gunn Rat Kernicterus Model
Principal Investigator: Fatemi, Seyed A.
The proposed project is the initial phase of a long-term endeavor to develop therapies that will help patients with dyskinetic cerebral palsy related to mitochondrial dysfunction and a Kernicterus-...
Activin Receptor-Based Therapies for Musculoskeletal Disease
Principal Investigator: Germain-Lee, Emily
Sponsored by the National Institute of Arthritis and Musculoskeletal and Skin Disease -- 1R01AR062074-04
The overall goal of this project is to investigate the role of the myostatin/activin signaling...
Phase 2 of Growth Hormone for Treatment of Albright Hereditary Osteodystrophy
Principal Investigator: Germain-Lee, Emily
Sponsored by the Food and Drug Administration -- 5R01FD003409-02.
Albright hereditary osteodystrophy (AHO) is a rare genetic disorder caused by heterozygous inactivating mutations in the gene...
Growth Hormone Use in Pseudohypoparathyroidism Type 1A
Principal Investigator: Germain-Lee, Emily
Sponsored by the Food and Drug Administration -- 7R01FD002568-04.
Albright hereditary osteodystrophy (AHO) is a rare genetic disorder caused by heterozygous inactivating mutations in the gene...
Osteogenesis Imperfecta Clinic
Principal Investigator: Germain-Lee, Emily
Sponsored by the Harry Headley Charitable & Research Foundation.
Funding for an independent clinician/researcher to work with Dr. Jay Shapiro in the OI Clinic.
Neurotrophin Protection of Hypoxic Ischemic Brain Injury
Principal Investigator: Hossain, Mir Ahamed
Perinatal hypoxia-ischemia (HI) is a major cause of life-long neurological disability such as cerebral palsy. There are few treatments available for this devastating disorder. For the next period of...
Screening of Neuropsychological Late Effects in Survivors of Childhood Cancer
Principal Investigator: Jacobson, Lisa
Sponsored by the Frank M. Ewing Foundation, Inc.
Because oncology patients present with many significant medical problems, physicians report that there is unfortunately insufficient, or very limited...
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