Clinical Research Projects

Analyzing Movement of Infants at Risk for Autism
Principal Investigator: Landa, Rebecca
Research question: 1) Will infants at high-risk for ASD display significantly different motions than infants identified as low-risk for ASD? 2) Can the effect of ASD on motor development be used as...
Autism Treatment Network: Program for the Comprehensive Care and Treatment of Autism
Principal Investigator: Landa, Rebecca
The purpose of this study is to improve medical treatment of children and adolescents with autism by establishing standards of clinical care based on clinical practice and evidence from clinical...
Early Detection, Intervention and Neurobiology in Autism: Early Intervention Portion
Principal Investigator: Landa, Rebecca
The overall goal of the study is to counter the effects of increased N-methyl-D-aspartate (NMDA)/glutamate receptors in mutation-positive Rett syndrome (RTT) subjects by use of dextromethorphan (DM...
Validation of a Video-Guided Screening Instrument for Autism Spectrum Disorders
Principal Investigator: Landa, Rebecca
The overarching goal of this proposed project is to assess the criterion validity of a new autism spectrum disorder (ASD) screening tool by comparing it to a gold standard ASD diagnostic tool known...
Development of a Social and Communication Intervention for Preschoolers with Autism
Principal Investigator: Landa, Rebecca
This is a multiphase study designed to examine the proposed intervention and how it translates for use in authentic educational settings by teachers of preschoolers with ASD. The primary aim of this...
Regulation of Glioblastoma Stem Cells by Kruppel-like Factors
Principal Investigator: Laterra, John
This research will examine mechanisms by which the family of Kruppel-like factors regulate the behavior, differentiation and tumor initiating ability of human GBM-derived stem cells. We will obtain...
Pilot Project to Assess Web-Based Family Recruitment for Autism Genetics Studies
Principal Investigator: Law, Paul
The overall goal of this project is to demonstrate that large-scale DNA collection is feasible and cost-effective. Aim 1: Demonstrate the accuracy of a rapid phenotyping paradigm in which affected...
Interactive Autism Network Research Database
Principal Investigator: Law, Paul
IAN will develop and maintain a national online research database for individuals affected by autism spectrum disorders (ASD) and their family members. This will allow targeted recruitment of...
Grandparents of Children with Autism Spectrum Disorders Survey
Principal Investigator: Law, Paul
The study will address the level of grandparent involvement in the lives of children with ASD. It will also address the impact of having a grandchild with an ASD on these grandparents in emotional,...
CAARE (Creating Advances in Autism through Research Engagement) Project
Principal Investigator: Law, Paul
The CAARE Project will develop and maintain an institutional research database for individuals affected by autism spectrum disorders (ASD) and their family members. This will allow targeted...
Determinants of Appointment Attendance at an Outpatient Pediatric Autism Clinic
Principal Investigator: Law, Paul
While most research has investigated psychometric assessment and clinical intervention for children with autism spectrum disorders (ASD), little is known about the factors that influence attendance...
Masqueraders of Cerebral Palsy
Principal Investigator: Lee, Ryan
Genetic conditions that manifest movement and postural impairment at perinatal or early childhood periods are often diagnosed with cerebral palsy. Identifying masqueraders of cerebral palsy...
The Medical Evaluation of Autism in Preschoolers: Examining the Discrepancies between Parental and Clinical Impressions
Principal Investigator: Leppert, Mary
The proposed study will examine a clinic population of children being evaluated for early developmental delays in order to investigate how often parents and clinicians differ in their opinions...
Disparities in Identification of Co-Morbid Diagnoses and Prescribing Practice in School Aged Children with ADHD: Comprehensive vs. Limited Evaluations
Principal Investigator: Leppert, Mary
We will conduct a retrospective chart review study of children 5-10 years of age, who present to the Kennedy Krieger Institute Center for Development and Learning for a new evaluation and are...
Trainee teaching, knowledge and attitudes of the risks, assessments and outcomes associated with preterm birth
Principal Investigator: Leppert, Mary
Presently, 11.9% of births in the United States are preterm. Preterm children who survive the neonatal period are at significantly higher risk for neurodevelopmental disabilities. We believe that the...
Prevalence of Latex Allergy in Children with Spina Bifida
Principal Investigator: Levey, Eric
This project has two goals: First, this study will assess how effective present day “latex avoidance” procedures have been in reducing latex sensitization among children who have been newly diagnosed...
Bowel and Bladder Continence Among Children with Spina Bifida: A Prospective Study
Principal Investigator: Levey, Eric
The lack of effective bladder and/or bowel control is a significant barrier to the normal social and emotional development of children and adolescents with Spina Bifida. The study proposed in this...
Continued Impairment in Adolescents Who Have Outgrown ADHD
Principal Investigator: Lipkin, Paul
Do adolescents who report that they have "outgrown" childhood Attention-Deficit/ Hyperactivity Disorder (ADHD) (diagnosed before age 10 years of age) continue to have symptoms of ADHD and impairment...
Outcome of Inclusion in Children with Pragmatic Language Impairment
Principal Investigator: Lipkin, Paul
To determine if there is a relationship between the level of academic support and reading comprehension level by evaluating the difference in reading comprehension level in third grade in children...
Developmental Surveillance and Screening Policy Implementation Project
Principal Investigator: Lipkin, Paul
The Developmental Surveillance and Screening Policy Implementation Project will select 15 pilot primary care pediatric practices to implement the AAP policy statement (anticipated publication of...
Handedness in Children with Mental Disorders
Principal Investigator: Logue, Dora
Is there a higher incidence of left handedness in children with mental health disorders? Is the severity of mental health disorders greater in children who are left handed compared to right handed...
Assessment of Neurocognitive Factors in Reading: Grades 4-8
Principal Investigator: Mahone, E. Mark
The focus of the current research is to examine the extent to and manner in which difficulties in component reading skills (both top down and bottom up), such as decoding accuracy, fluency, and...
ADHD in Preschool Girls: Longitudinal Analysis of Neuroimaging and Behavior
Principal Investigator: Mahone, Mark
The overall goal of this project is to characterize the anomalous early development (brain, cognition, and behavior) of girls who present with the behavioral features of Attention Deficit...
Neuroimaging of Motor Stereotypies in Children with Autism
Principal Investigator: Mahone, Mark
Complex motor stereotypies (i.e., apparently purposeless, rhythmical, repetitive movements) represent one of the core criteria—together with restricted interests, preoccupations, and rigidity—for...
The Effects of ADHD (Beyond Decoding Accuracy) on Reading Fluency and Comprehension
Principal Investigator: Mahone, Mark
The central goal of this project is to understand how ADHD influences processing speed (as it relates to reading speed/fluency), working memory, and reading comprehension. Specifically, we will...
ADHD in girls: neuroimaging and executive behavior
Principal Investigator: Mahone, Mark
This study is closed to participant accural and we are currently writing papers. This is a proposal to determine whether ADHD is associated with different brain anomalies/abnormalities in girls and...
Neurobehavioral Late-Effects in Pediatric Brain Tumors
Principal Investigator: Mahone, Mark
Radiation Therapy (RT) has been largely responsible for improving the survival rates of children with certain types of brain tumors, although this has come at a cost in terms of the neurodevelopment...
Frontostriatal Glutamate in ADHD: Neuropsychological and Behavioral Correlates
Principal Investigator: Mahone, Mark
Glutamate is an excitatory amino acid and the most abundant neurotransmitter in the brain. Glutamate levels are linked to a variety of neurological and psychiatric disorders, and have been implicated...
The Incremental Validity of Neuropsychological Assessment in the Identification and Treatment of Attention Deficit/Hyperactivity Disorder
Principal Investigator: Mahone, Mark
The aim of this study is to determine the extent to which neuropsychological assessment contributes to the treatment of ADHD in terms of symptom reduction and quality of life. This is designed to be...
Prevalence of Reading Difficulties: 4th-8th Grade
Principal Investigator: Mahone, E. Mark
The central goal of this project is to estimate the prevalence of various types of reading disability (RD) in the population of upper elementary and middle school students (grades 4 and 8). All data...
Reading Disability in Grades 3 - 8: Neurocognitive Factors and Behavioral Assessment
Principal Investigator: Mahone, E. Mark
This project has two purposes: to examine the validity of a response-to-intervention (RTI) approach to identifying children with reading disabilities (RD) who are beyond the initial stages of...
Genetic Influences on Sluggish Cognitive Tempo and Reading
Principal Investigator: Mahone, Mark
The overall goal of this pilot study is to examine the relationships between neuropsychological skills and genetic polymorphisms of children ages 8-15 years who display slowed processing speed in the...
Neural Correlates of Mathematical Skills and Performance
Principal Investigator: Mazzocco, Michele
In a recent publication, we demonstrated that there are large individual differences in adolescents’ numerical acuity, and that 14-year-olds’ numerical acuity is retroactively predictive of their...
SIMS -- Spinal Cord Injury Management System
Principal Investigator: McDonald, John
To define the treatment modality and co-factor variables which influence the response to Activity Based Restorative Therapies (ABRT) in individuals with Spinal Cord Injury (SCI). To define the dose...
Localized Growth Factor Effects on Myelination by hESC Derived Oligodendrocytes in a Novel Microfluidic Platform
Principal Investigator: McDonald, John
Human embryonic stem cells (hESCs) are capable of growing into any type of cell in the body. Therefore, they may someday be used to repair or replace diseased tissue and even entire organs. Our focus...
Creating a Pediatric Imaging-Genomics Data Resource
Principal Investigator: Mostofsky, Stewart
Along with investigators at 8 other sites across the U.S., we will assemble a large, cross-sectional imaging-genomics dataset. The major aim of our proposal is to create a database that is...
Anomalus Motor Physiology in ADHD
Principal Investigator: Mostofsky, Stewart
The hypothesis of this study is that the neuromotor anomalies present in children with ADHD will be associated with deficient intracortical and interhemispheric inhibition of the motor cortex. This...
Neurologic basis of inhibitory deficits in ADHD
Principal Investigator: Mostofsky, Stewart
Prevailing hypotheses implicate deficient response inhibition as one of the fundamental features driving the pathophysiology of ADHD. Results from studies of lesions in animals and humans led many...
Tourette Syndrome: Functional imaging of motor activation pathways in verbal and motor tics
Principal Investigator: Mostofsky, Stewart
Motor skill learning in autism: assessment and treatment of altered patterns of learning.
Principal Investigator: Mostofsky, Stewart
Detailed study of motor impairments in autism can provide valuable insights into the neural basis of the disorder and help to guide its treatment. Given the developmental nature of autism, during the...
Motor Skill Learning in Autism
Principal Investigator: Mostofsky, Stewart
Abnormalities on motor examination have often afforded valuable insights into developmental disorders of the brain; such abnormalities have been well documented in individuals with autism and, in...
Pathogenesis of Rett Syndrome
Principal Investigator: Naidu, SakkuBai
This is an observational study of the natural history and clinical course of Rett Syndrome (RTT), a neurodevelopmental disorder primarily affecting females, caused by mutations in the MeCP2 gene. Our...
KKI Weblink for researchers in Rett Syndrome
Principal Investigator: Naidu, SakkuBai
Creation of a Weblink for Researchers in Rett syndrome to request de-identified data from clinical evaluations collected on our patients with Rett syndrome (RTT) in The Natural History study "...
Dextromethorphan in Rett syndrome
Principal Investigator: Naidu, SakkuBai
Dr. SakkuBai Naidu of the Kennedy Krieger Institute is initiating a clinical drug trial using dextromethorphan (DM) in Rett Syndrome (RTT) at the Pediatric Clinical Research Unit (PCRU) of the Johns...
Placebo-Controlled Trial of Dextromethorphan in Rett Syndrome
Principal Investigator: Naidu, SakkuBai
The overall goal of this study is to counter the effects of increased N-methyl-D-aspartate (NMDA)/glutamate receptors in MeCP2-mutation-positive Rett syndrome (RTT) subjects by use of a placebo-...
Genetic Modifiers of Conduction Disease Risk in Myotonic Dystrophy
Principal Investigator: Nazarian, Saman
Co-Principal Investigator: Kathryn Wagner This multi-center case controlled observational study is established to determine if genetic variants that are known to modulate cardiac conduction and...
Physical, Functional and Neurological Effects of Two Lower Extremity Exercise Protocols in Children with Cerebral Palsy
Principal Investigator: Pekar, James
The primary site for this study is the National Institutes of Health Clinical Center with Dr. Diane Damiano as the principal investigator. All study participants will be consented and enrolled at the...
Chromosomal abnormalities underlying developmental disabilities
Principal Investigator: Pevsner, Jonathan
The research question we would like to address is whether children with developmental disabilities have identifiable chromosomal abnormalities. The approach is in four parts:(1) prescreen and recruit...
Pediatric Constraint-Induced Movement Therapy for Children with Hemiparesis: Outcomes of a Clinical Model
Principal Investigator: Pidcock, Frank
Does the function of children with hemiparesis improve after treatment involving constraint of the less impaired upper extremity in conjunction with intensive therapies? We will investigate this...
Using Xbox Kinect based sensory technology to improve the functional mobility by allowing remote monitoring and modification of therapeutic activities for children with Cerebral Palsy in the home
Principal Investigator: Pidcock, Frank
This is a small fesibility study where Kennedy Krieger will partner with Richard Simpson a rehabilitation engineer to provide the therapeutic and technologic resources for developing and implementing...
Effect of the NICU Therapy Initiative on Length of Stay
Principal Investigator: Pidcock, Frank
Problem: There is a lack of evidence regarding the impact of interventions by physical therapy and occupational therapy on length of stay in the neonatal intensive care unit (NICU) at the Johns...
Outpatient Research Registry
Principal Investigator: Pritchard, Alison
The primary objective of this protocol is to gather information on Neuropsychology outpatients that can later be accessed for screening purposes (to determine eligibility for research studies...
Executive Function and Academic Achievement in Children with a History of Prematurity
Principal Investigator: Pritchard, Alison
The proposed study will be a retrospective review of previously collected clincal neuropsychological testing data, which will be deidentified for the purpose of this research study. The first...
Effect of glycerol trierucate on clinical course of Adrenoleukodystrophy
Principal Investigator: Raymond, Gerald
Adrenoleukodystrophy is a disorder of very long chain fatty acids secondary to defects in peroxisomal beta oxidation. The accumulation of these fatty acids results in a disorder of the adrenal glands...
Compassionate usage of Lorenzo's Oil in peroxisomal disorders
Principal Investigator: Raymond, Gerald
Lorenzo's oil, a mixture of glyceryl trioleate and glyceryl trierucate, lowers very long chain fatty acids in X-linked adrenoleukodystrophy. There is preliminary data that lowering very long chain...