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Neuroimaging and Neurobehavioral Outcomes of Pediatric Neuromyelitis Optica: A Pilot Study

Principal Investigator:
Ana
Arenivas

The primary objective of this proposed prospective pilot study, entitled “Neuroimaging and Neurobehavioral Outcomes of Pediatric Neuromyelitis Optica: A Pilot Study” is to determine the utility of specific neuroimaging modalities as biomarkers of Neuromyelitis Optica (NMO) using MPRAGE, diffusion tensor imaging (DTI), magnetization transfer magnetic resonance imaging (MRI), resting state functional connectivity MRI (rs-fcMRI), quantitative susceptibility mapping (QSM) neuroimaging modalities at 3.0 Tesla field strength. 

The purpose will be to identify the utility of each approach to distinguish between typically developing individuals and individuals with demyelinating disorders, as well as the utility of each approach to distinguish between groups of demyelinating disorders. It is anticipated that neuroimaging biomarkers will discriminate between these clinical groups and typically developing controls as well as between clinical groups. 

Furthermore, it will be determined whether the observed differences have clinical significance, in that degree of functional or structural compromise will have clinical implications in pediatric demyelinating disorders with metrics derived from these modalities being positively associated with clinical and functional outcome measures among participants.

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