Distal Femur Bone Mineral Density Measurements in Healthy Individuals and Individuals with Acquired and Genetic Bone Disorders

Medical reports and our preliminary data indicate that DXA bone density measurements at the distal femur are sensitive indicators of the extent bone demineralization. Although data at this femur site have been obtained in children, there is no comparable adult database. Also, the utility of these measurements as compared with standard DXA measurements in disorders characterized by demineralization has not been assessed. This study will include healthy individuals and patients with spinal cord injury and Osteogenesis Imperfecta studied at the McGuire VA Medical Center Richmond and the Kennedy Krieger Institute.