Bladder stone risk analysis in patients with spina bifida

Spina bifida patients who have undergone bladder augmentation are at increased risk for the formation of bladder stones. Treating these bladder stones usually requires surgical intervention and increases morbidity. Although several mechanisms have been proposed to explain this, no formal comparison of 24 hour urine parameters has been done. We would like to compare 24 hour urines and serum chemistries on spina bifida patients with bladder augmentations who have a history of stone formation, patients with bladder augmentations who have never had a bladder stone, and patients without bladder augmentation who perform clean intermittent catheterization. We hope to use the information obtained by these 24 hour urines to develop a therapeutic plan to help reduce the risk of bladder stone formation.