Whole-body imaging of high-dose ionizing irradiation-induced tissue injuries using 99mTc-duramycin.

TitleWhole-body imaging of high-dose ionizing irradiation-induced tissue injuries using 99mTc-duramycin.
Publication TypeJournal Article
Year of Publication2013
AuthorsJohnson SE, Li Z, Liu Y, Moulder JE, Zhao M
JournalJournal of nuclear medicine : official publication, Society of Nuclear Medicine
Volume54
Issue8
Pagination1397-403
Date Published2013 Aug
Abstract

High-dose ionizing irradiation can cause extensive injuries in susceptible tissues. A noninvasive imaging technique that detects a surrogate marker of apoptosis may help characterize the dynamics of radiation-induced tissue damage. The goal of this study was to prove the concept of imaging the temporal and spatial distribution of damage in susceptible tissues after high-dose radiation exposure, using (99m)Tc-duramycin as a phosphatidylethanolamine-binding radiopharmaceutical.

DOI10.4161/cib.24493
Alternate JournalJ. Nucl. Med.