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Whole-body imaging of high-dose ionizing irradiation-induced tissue injuries using 99mTc-duramycin.
|Title||Whole-body imaging of high-dose ionizing irradiation-induced tissue injuries using 99mTc-duramycin.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Johnson SE, Li Z, Liu Y, Moulder JE, Zhao M|
|Journal||Journal of nuclear medicine : official publication, Society of Nuclear Medicine|
|Date Published||2013 Aug|
High-dose ionizing irradiation can cause extensive injuries in susceptible tissues. A noninvasive imaging technique that detects a surrogate marker of apoptosis may help characterize the dynamics of radiation-induced tissue damage. The goal of this study was to prove the concept of imaging the temporal and spatial distribution of damage in susceptible tissues after high-dose radiation exposure, using (99m)Tc-duramycin as a phosphatidylethanolamine-binding radiopharmaceutical.
|Alternate Journal||J. Nucl. Med.|