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Volutrauma, but not Atelectrauma, Induces Systemic Cytokine Production by Lung-Marginated Monocytes*.
|Title||Volutrauma, but not Atelectrauma, Induces Systemic Cytokine Production by Lung-Marginated Monocytes*.|
|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Wakabayashi K, Wilson MR, Tatham KC, O'Dea KP, Takata M|
|Journal||Critical care medicine|
|Date Published||2014 Jan|
Ventilator-induced lung injury has substantive impact on mortality of patients with acute respiratory distress syndrome. Although low tidal volume ventilation has been shown to reduce mortality, clinical benefits of open-lung strategy are controversial. In this study, we investigated the impact of two distinct forms of ventilator-induced lung injury, i.e., volutrauma and atelectrauma, on the progression of lung injury and inflammation, in particular alveolar and systemic cytokine production.
|Alternate Journal||Crit. Care Med.|