In vitro Screening of Compounds against Laboratory and Field Isolates of Human Hookworm Reveals Quantitative Differences in Anthelminthic Susceptibility.

TitleIn vitro Screening of Compounds against Laboratory and Field Isolates of Human Hookworm Reveals Quantitative Differences in Anthelminthic Susceptibility.
Publication TypeJournal Article
Year of Publication2013
AuthorsTreger RS, Otchere J, Keil MF, Quagraine JE, Rai G, Mott BT, Humphries DL, Wilson M, Cappello M, Vermeire JJ
JournalThe American journal of tropical medicine and hygiene
Date Published2013 Dec 2
Abstract

A panel of 80 compounds was screened for anthelminthic activity against a laboratory strain of Ancylostoma ceylanicum and field isolates of hookworm obtained from school children in the Kintampo North District of the Brong Ahafo Region of Ghana. Although the laboratory strain of A. ceylanicum was more susceptible to the compounds tested than the field isolates of hookworm, a twofold increase in compound concentration resulted in comparable egg hatch percent inhibition for select compounds. These data provide evidence that the efficacy of anthelminthic compounds may be species-dependent and that field and laboratory strains of hookworm differ in their sensitivities to the anthelminthics tested. These data also suggest that both compound concentration and hookworm species must be considered when screening to identify novel anthelminthic compounds.

DOI10.1073/pnas.1317807110
Alternate JournalAm. J. Trop. Med. Hyg.