In vitro activity of sodium new houttuyfonate alone and in combination with oxacillin or netilmicin against methicillin-resistant Staphylococcus aureus.

TitleIn vitro activity of sodium new houttuyfonate alone and in combination with oxacillin or netilmicin against methicillin-resistant Staphylococcus aureus.
Publication TypeJournal Article
Year of Publication2013
AuthorsLu X, Yang X, Li X, Lu Y, Ren Z, Zhao L, Hu X, Jiang J, You X
JournalPloS one
Volume8
Issue7
Paginatione68053
Date Published2013
Abstract

Staphylococcus aureus can cause severe infections, including bacteremia and sepsis. The spread of methicillin-resistant Staphylococcus aureus (MRSA) highlights the need for novel treatment options. Sodium new houttuyfonate (SNH) is an analogue of houttuynin, the main antibacterial ingredient of Houttuynia cordata Thunb. The aim of this study was to evaluate in vitro activity of SNH and its potential for synergy with antibiotics against hospital-associated MRSA.

DOI10.1371/journal.pone.0068568
Alternate JournalPLoS ONE