Visceral nociceptive afferent facilitates reaction of subnucleus reticularis dorsalis to acupoint stimulation in rats.

TitleVisceral nociceptive afferent facilitates reaction of subnucleus reticularis dorsalis to acupoint stimulation in rats.
Publication TypeJournal Article
Year of Publication2013
AuthorsLi L, Yu L, Rong P, Ben H, Li X, Zhu B, Chen R
JournalEvidence-based complementary and alternative medicine : eCAM
Volume2013
Pagination931283
Date Published2013
Abstract

Objective. To explore the area and sensitization variance of acupoint when internal organs are under pathological condition. To observe quantity-effect variance of subnucleus reticularis dorsalis (SRD) to electroacupuncture under both physiological and pathological conditions. To explain medulla oblongata mechanism of acupoint sensitization. Method. Mustard oil was imported into colon and rectum of 20 male SD rats in order to observe its influence on acupoint sensitization. SRD neuron activity was recorded. Visceral nociceptive stimulus was generated by colorectal distension (CRD). Quantity-effect variance of neuron activity to electroacupuncture to "Zusanli-Shangjuxu" area both before and after CRD was observed. Paired t-test is used for cross-group comparison; P < 0.05 is deemed as of statistical differences. Result. Visceral inflammation could facilitate SRD neuron activity to acupoint stimulation. Visceral nociceptive afference could enhance neuron activity to acupoint acupuncture. Wide dynamic range (WDR) neuron activity caused by electroacupuncture increased when visceral nociception increased. Conclusion. The size and function of the acupoints comply with the functionality of the internal organs. The sensitive degree of acupoints changed according to malfunction of internal organs.

DOI10.1371/journal.pone.0065940
Alternate JournalEvid Based Complement Alternat Med