Validation of DTI Tractography-Based Measures of Primary Motor Area Connectivity in the Squirrel Monkey Brain.

TitleValidation of DTI Tractography-Based Measures of Primary Motor Area Connectivity in the Squirrel Monkey Brain.
Publication TypeJournal Article
Year of Publication2013
AuthorsGao Y, Choe AS, Stepniewska I, Li X, Avison MJ, Anderson AW
JournalPloS one
Volume8
Issue10
Paginatione75065
Date Published2013
Abstract

Diffusion tensor imaging (DTI) tractography provides noninvasive measures of structural cortico-cortical connectivity of the brain. However, the agreement between DTI-tractography-based measures and histological 'ground truth' has not been quantified. In this study, we reconstructed the 3D density distribution maps (DDM) of fibers labeled with an anatomical tracer, biotinylated dextran amine (BDA), as well as DTI tractography-derived streamlines connecting the primary motor (M1) cortex to other cortical regions in the squirrel monkey brain. We evaluated the agreement in M1-cortical connectivity between the fibers labeled in the brain tissue and DTI streamlines on a regional and voxel-by-voxel basis. We found that DTI tractography is capable of providing inter-regional connectivity comparable to the neuroanatomical connectivity, but is less reliable measuring voxel-to-voxel variations within regions.

DOI10.1242/bio.20132279
Alternate JournalPLoS ONE