In utero beta 2 adrenergic agonist exposure and adverse neurophysiologic and behavioral outcomes.

TitleIn utero beta 2 adrenergic agonist exposure and adverse neurophysiologic and behavioral outcomes.
Publication TypeJournal Article
Year of Publication2009
AuthorsWitter FR, Zimmerman AW, Reichmann JP, Connors SL
JournalAmerican journal of obstetrics and gynecology
Volume201
Issue6
Pagination553-9
Date Published2009 Dec
Abstract

Beta 2 adrenergic receptor overstimulation during critical periods of prenatal development can induce a permanent shift in the balance of sympathetic-to-parasympathetic tone. This is a biologically plausible mechanism whereby beta 2 adrenergic agonists can induce functional and behavioral teratogenesis, which explains their association with increases in autism spectrum disorders, psychiatric disorders, poor cognitive, motor function and school performance, and changes in blood pressure in the offspring. The use of beta 2 adrenergic agonists should be limited to proven indications when alternate drugs are ineffective or unavailable; the risks of untreated disease to the mother and fetus are greater than the risk of the beta 2 adrenergic agonist.

DOI10.1177/0883073809350221
Alternate JournalAm. J. Obstet. Gynecol.