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Use of hyperspectral imaging for label-free decoding and detection of biomarkers.
|Title||Use of hyperspectral imaging for label-free decoding and detection of biomarkers.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Wang T, Li Q, Li X, Zhao S, Lu Y, Huang G|
|Date Published||2013 May 1|
Detecting the existence of biomarkers is one of the most important issues in molecular diagnosis. This Letter presents a label-free decoding and detection method for biomarker tests based on hyperspectral imaging and interferometry. The decoding and detection results were extracted from a single hyperspectral image with different spectrum-to-thickness reconstructing algorithms, which made the testing procedure extremely fast and simple. The coding capacity of this method is more than 400, and the detection sensitivity can reach 2 ng/mm2 without fluorescent labeling.
|Alternate Journal||Opt Lett|