Use of hyperspectral imaging for label-free decoding and detection of biomarkers.

TitleUse of hyperspectral imaging for label-free decoding and detection of biomarkers.
Publication TypeJournal Article
Year of Publication2013
AuthorsWang T, Li Q, Li X, Zhao S, Lu Y, Huang G
JournalOptics letters
Volume38
Issue9
Pagination1524-6
Date Published2013 May 1
Abstract

Detecting the existence of biomarkers is one of the most important issues in molecular diagnosis. This Letter presents a label-free decoding and detection method for biomarker tests based on hyperspectral imaging and interferometry. The decoding and detection results were extracted from a single hyperspectral image with different spectrum-to-thickness reconstructing algorithms, which made the testing procedure extremely fast and simple. The coding capacity of this method is more than 400, and the detection sensitivity can reach 2 ng/mm2 without fluorescent labeling.

DOI10.1113/jphysiol.2013.258301
Alternate JournalOpt Lett