Upregulation of miR-370 contributes to the progression of gastric carcinoma via suppression of FOXO1.

TitleUpregulation of miR-370 contributes to the progression of gastric carcinoma via suppression of FOXO1.
Publication TypeJournal Article
Year of Publication2013
AuthorsFan C, Liu S, Zhao Y, Han Y, Yang L, Tao G, Li Q, Zhang L
JournalBiomedicine & pharmacotherapy = Biomédecine & pharmacothérapie
Volume67
Issue6
Pagination521-6
Date Published2013 Jul
Abstract

FOXO1 is downregulated in a number of cancers. However, the underlying mechanisms are poorly understood. In this study, we report that the expression of miR-370 was upregulated in gastric cancer cell lines and gastric cancer tissues. Overexpression of miR-370 in gastric cancer cells promoted the cell proliferation and anchorage-independent growth, while silencing of miR-370 showed opposite effects. miR-370-induced proliferation was correlated with the downregulation of cyclin-dependent kinase inhibitors, p27(Kip1) and p21(Cip1), and the upregulation of the cell cycle regulator cyclin D1. Furthermore, we identified that FOXO1 is the functional target of miR-370. Restored expression of FOXO1 together with miR-370 strongly abrogated miR-370-induced cell proliferation. Taken together, our results revealed a novel mechanism of FOXO1 suppression mediated by miR-370 in gastric cancer.

DOI10.1371/journal.pone.0074809
Alternate JournalBiomed. Pharmacother.