Underlying protective mechanism of α1-adrenoceptor activation against irradiation-induced damage in rat submandibular gland.

TitleUnderlying protective mechanism of α1-adrenoceptor activation against irradiation-induced damage in rat submandibular gland.
Publication TypeJournal Article
Year of Publication2013
AuthorsXiang B, Li X-X, Zhang F-Y
JournalArchives of oral biology
Volume58
Issue9
Pagination1238-45
Date Published2013 Sep
Abstract

Damage to salivary gland after radiotherapy for head and neck malignant tumours can lead to irreversible oral complaints, which severely impair quality of life. The protective effect of α1-adrenoceptor activation on the salivary glands after irradiation has previously been demonstrated. However, the exact mechanism remains unclear. In this study, we investigated the underlying cytoprotective mechanism of α1-adrenoceptor activation in rat submandibular glands after irradiation.

DOI10.1002/gcc.22099
Alternate JournalArch. Oral Biol.