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Ultraviolet B enhances DNA hypomethylation of CD4+ T cells in systemic lupus erythematosus via inhibiting DNMT1 catalytic activity.
|Title||Ultraviolet B enhances DNA hypomethylation of CD4+ T cells in systemic lupus erythematosus via inhibiting DNMT1 catalytic activity.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Wu Z, Li X, Qin H, Zhu X, Xu J, Shi W|
|Journal||Journal of dermatological science|
|Date Published||2013 Sep|
CD4+ T cells DNA hypomethylation is involved in the pathogenesis of systemic lupus erythematosus (SLE). Recent studies showed that ultraviolet B (UVB, 290-320 nm) might induce the exacerbation of SLE by decreasing the DNA methylation level. However, the role of DNA methyltransferase 1 (DNMT1) in the UVB-induced CD4+ T cells DNA hypomethylation remains unclear.
|Alternate Journal||J. Dermatol. Sci.|