Ultrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives.

TitleUltrasound-Promoted One-Pot, Four-Component Synthesis of Pyridin-2(1H)-One Derivatives.
Publication TypeJournal Article
Year of Publication2013
AuthorsYang J, Li Q, Zhang J, Lin W, Wang J, Wang Y, Huang Z, Shi D
JournalMolecules (Basel, Switzerland)
Volume18
Issue12
Pagination14519-28
Date Published2013
Abstract

An efficient one-pot synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydro- pyridine-3,5-dicarbonitrile derivatives by four-component piperidine-catalyzed reactions of a ketone, malononitrile, ethyl cyanoacetate and hydrazine hydrate under ultrasound irradiation is described. This method provides several advantages such as shorter reaction times, excellent yields, and a simple workup procedure.

DOI10.1073/pnas.1317807110
Alternate JournalMolecules