TRO19622 promotes myelin repair in a rat model of demyelination.

TitleTRO19622 promotes myelin repair in a rat model of demyelination.
Publication TypeJournal Article
Year of Publication2013
AuthorsLi Y, Zhang Y, Han W, Hu F, Qian Y'e, Chen Q
JournalThe International journal of neuroscience
Volume123
Issue11
Pagination810-22
Date Published2013 Nov
Abstract

Multiple sclerosis is a neurodegenerative autoimmune disease characterized by diffuse oligodendrocyte injury, axonal loss and multifocal demyelination of myelin sheaths in the central nervous system. TRO19622 is a small cholesterol-like compound, which displays remarkable neuroprotective and neuroregenerative properties in neural cell culture and rodent models of nerve trauma. Therefore, the aim of the present study is to evaluate the pharmacological action of TRO19622 on the demyelination/remyelination processes by using a rat model of cuprizone-induced demyelination.

DOI10.1002/gcc.22099
Alternate JournalInt. J. Neurosci.