Triterpenoids and steroids with cytotoxic activity from Emmenopterys henryi.

TitleTriterpenoids and steroids with cytotoxic activity from Emmenopterys henryi.
Publication TypeJournal Article
Year of Publication2013
AuthorsWu X-D, He J, Li X-Y, Dong L-B, Gong X, Gao X, Song L-D, Li Y, Peng L-Y, Zhao Q-S
JournalPlanta medica
Volume79
Issue14
Pagination1356-61
Date Published2013 Sep
Abstract

Two new ursane-type triterpenoids, 3β,19α,23-trihydroxyurs-12-en-24-al-28-oic acid (1) and 3β,19α,24-trihydroxy-23-norurs-12-en-28-oic acid (2), two new pregnane derivatives, 3β,12β-dihydroxy-5α-pregnane-14,16-dien-20-one (9) and 12β-hydroxy-5α-pregnane-14,16-dien-3,20-dione (10), and eight known compounds were isolated from the twigs and leaves of Emmenopterys henryi. The structures of the new compounds were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR experiments. Compounds 4, 11, and 12 showed cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines with IC50 values in the range of 3.11-20.12 µM.

DOI10.1128/JVI.01190-13
Alternate JournalPlanta Med.