Triptolide induces suppressor of cytokine signaling-3 expression and promotes lamina propria mononuclear cells apoptosis in Crohn's colitis.

TitleTriptolide induces suppressor of cytokine signaling-3 expression and promotes lamina propria mononuclear cells apoptosis in Crohn's colitis.
Publication TypeJournal Article
Year of Publication2013
AuthorsLi Y, Tian Y, Zhu W, Gong J, Zhang W, Yu C, Gu L, Li N, Li J
JournalInternational immunopharmacology
Volume16
Issue2
Pagination268-74
Date Published2013 Jun
Abstract

IL-6/STAT3/SOCS3 signaling pathway plays an important role in the pathogenesis of Crohn's disease by induction of the antiapoptotic factors Bcl-2 and Bcl-xl in lamina propria mononuclear cells (LPMCs). We previously reported that triptolide showed therapeutic activity in mouse colitis by mechanisms involving suppression of IL-6 trans-signaling. IL-10 gene-deficient mice with established colitis were used for the experiments with triptolide administration.

DOI10.1111/tpj.12228
Alternate JournalInt. Immunopharmacol.