Trichostatin A Stabilizes the Expression of Pluripotent Genes in Human Mesenchymal Stem Cells during Ex Vivo Expansion.

TitleTrichostatin A Stabilizes the Expression of Pluripotent Genes in Human Mesenchymal Stem Cells during Ex Vivo Expansion.
Publication TypeJournal Article
Year of Publication2013
AuthorsHan B, Li J, Li Z, Guo L, Wang S, Liu P, Wu Y
JournalPloS one
Volume8
Issue11
Paginatione81781
Date Published2013
Abstract

Mesenchymal stem cells (MSCs) have been considered as ideal cells for the treatment of a variety of diseases. However, aging and spontaneous differentiation of MSCs during culture expansion dampen their effectiveness. Previous studies suggest that ex vivo aging of MSCs is largely caused by epigenetic changes particularly a decline of histone H3 acetylation levels in promoter regions of pluripotent genes due to inappropriate growth environment.

DOI10.1155/2013/865181
Alternate JournalPLoS ONE