Transplantation of myoblast sheets that secrete the novel peptide SVVYGLR improves cardiac function in failing hearts.

TitleTransplantation of myoblast sheets that secrete the novel peptide SVVYGLR improves cardiac function in failing hearts.
Publication TypeJournal Article
Year of Publication2013
AuthorsUchinaka A, Kawaguchi N, Hamada Y, Mori S, Miyagawa S, Saito A, Sawa Y, Matsuura N
JournalCardiovascular research
Volume99
Issue1
Pagination102-10
Date Published2013 Jul 1
Abstract

Transplantation of myoblast sheets is a promising therapy for enhancing cardiac function after heart failure. We have previously demonstrated that a 7-amino-acid sequence (Ser-Val-Val-Tyr-Gly-Leu-Arg) derived from osteopontin (SV peptide) induces angiogenesis. In this study, we evaluated the long-term therapeutic effects of myoblast sheets secreting SV in a rat infarction model.

DOI10.1007/s13181-013-0310-2
Alternate JournalCardiovasc. Res.