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Transplantation of myoblast sheets that secrete the novel peptide SVVYGLR improves cardiac function in failing hearts.
|Title||Transplantation of myoblast sheets that secrete the novel peptide SVVYGLR improves cardiac function in failing hearts.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Uchinaka A, Kawaguchi N, Hamada Y, Mori S, Miyagawa S, Saito A, Sawa Y, Matsuura N|
|Date Published||2013 Jul 1|
Transplantation of myoblast sheets is a promising therapy for enhancing cardiac function after heart failure. We have previously demonstrated that a 7-amino-acid sequence (Ser-Val-Val-Tyr-Gly-Leu-Arg) derived from osteopontin (SV peptide) induces angiogenesis. In this study, we evaluated the long-term therapeutic effects of myoblast sheets secreting SV in a rat infarction model.
|Alternate Journal||Cardiovasc. Res.|