Transient overexpression of Pparγ2 and C/ebpα in mesenchymal stem cells induces brown adipose tissue formation.

TitleTransient overexpression of Pparγ2 and C/ebpα in mesenchymal stem cells induces brown adipose tissue formation.
Publication TypeJournal Article
Year of Publication2013
AuthorsSheyn D, Pelled G, Tawackoli W, Su S, Ben-David S, Gazit D, Gazit Z
JournalRegenerative medicine
Volume8
Issue3
Pagination295-308
Date Published2013 May
Abstract

Brown adipose tissue plays a pivotal role in mammal metabolism and thermogenesis. It has a great therapeutic potential in several metabolic disorders such as obesity and diabetes. Mesenchymal stem cells (MSCs) are suitable candidates for brown adipose tissue formation de novo. Pparγ2 and C/ebpα are nucleic receptors known to mediate adipogenic differentiation. We hypothesized that overexpression of the Pparγ2 and C/ebpα genes in MSCs would lead to the formation of adipose tissue.

DOI10.1007/s13277-013-0935-4
Alternate JournalRegen Med