Tiam1 transgenic mice display increased tumor invasive and metastatic potential of colorectal cancer after 1,2-dimethylhydrazine treatment.

TitleTiam1 transgenic mice display increased tumor invasive and metastatic potential of colorectal cancer after 1,2-dimethylhydrazine treatment.
Publication TypeJournal Article
Year of Publication2013
AuthorsYu L-N, Zhang Q-L, Li X, Hua X, Cui Y-M, Zhang N-J, Liao W-T, Ding Y-Q
JournalPloS one
Volume8
Issue9
Paginatione73077
Date Published2013
Abstract

T lymphoma invasion and metastasis 1 (Tiam1) is a potential modifier of tumor development and progression. Our previous study in vitro and in nude mice suggested a promotion role of Tiam1 on invasion and metastasis of colorectal cancer (CRC). In the present study, we generated Tiam1/C1199-CopGFP transgenic mice to investigate the tumorigenetic, invasive and metastatic alterations in the colon and rectum of wild-type and Tiam1 transgenic mice under 1,2-dimethylhydrazine (DMH) treatment.

DOI10.1007/s12011-013-9822-5
Alternate JournalPLoS ONE