Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging.

TitleThree-dimensional tracking of axonal projections in the brain by magnetic resonance imaging.
Publication TypeJournal Article
Year of Publication1999
AuthorsMori S, Crain BJ, Chacko VP, van Zijl PC
JournalAnnals of neurology
Volume45
Issue2
Pagination265-9
Date Published1999 Feb
Abstract

The relationship between brain structure and complex behavior is governed by large-scale neurocognitive networks. The availability of a noninvasive technique that can visualize the neuronal projections connecting the functional centers should therefore provide new keys to the understanding of brain function. By using high-resolution three-dimensional diffusion magnetic resonance imaging and a newly designed tracking approach, we show that neuronal pathways in the rat brain can be probed in situ. The results are validated through comparison with known anatomical locations of such fibers.

Alternate JournalAnn. Neurol.