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Therapeutic implications of mesenchymal stem cells in acute lung injury/acute respiratory distress syndrome.
|Title||Therapeutic implications of mesenchymal stem cells in acute lung injury/acute respiratory distress syndrome.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Wang Y-Y, Li X-Z, Wang L-B|
|Journal||Stem cell research & therapy|
|Date Published||2013 May 2|
Acute lung injury (ALI), and its more severe form, acute respiratory distress syndrome (ARDS), are syndromes of acute hypoxemic respiratory failure resulting from a variety of direct and indirect injuries to the gas exchange parenchyma of the lungs. Current treatment of ALI/ARDS is primarily supportive, with lung protective ventilation and fluid conserving strategies. Despite improvement in these strategies, recent data indicate that the mortality of ALI/ARDS is still as high as 30 to 50%. Thus, there is a need for innovative therapies to further improve clinical outcomes of ALI/ARDS. Recent studies involving the administration of mesenchymal stem cells (MSCs) for the treatment of experimental ALI/ARDS have shown promising results. This review focuses on existing studies that have tested the use of MSCs in models of ALI/ARDS, and the potential mechanisms underlying their therapeutic effects.
|Alternate Journal||Stem Cell Res Ther|