Telomerase inhibition targets clonogenic multiple myeloma cells through telomere length-dependent and independent mechanisms.

TitleTelomerase inhibition targets clonogenic multiple myeloma cells through telomere length-dependent and independent mechanisms.
Publication TypeJournal Article
Year of Publication2010
AuthorsBrennan SK, Wang Q, Tressler R, Harley C, Go N, Bassett E, Huff CA, Jones RJ, Matsui W
JournalPloS one
Volume5
Issue9
Date Published2010
Abstract

Plasma cells constitute the majority of tumor cells in multiple myeloma (MM) but lack the potential for sustained clonogenic growth. In contrast, clonotypic B cells can engraft and recapitulate disease in immunodeficient mice suggesting they serve as the MM cancer stem cell (CSC). These tumor initiating B cells also share functional features with normal stem cells such as drug resistance and self-renewal potential. Therefore, the cellular processes that regulate normal stem cells may serve as therapeutic targets in MM. Telomerase activity is required for the maintenance of normal adult stem cells, and we examined the activity of the telomerase inhibitor imetelstat against MM CSC. Moreover, we carried out both long and short-term inhibition studies to examine telomere length-dependent and independent activities.

DOI10.1097/BRS.0b013e3181e7d675
Alternate JournalPLoS ONE