Targeting TGF-β signaling in cancer.

TitleTargeting TGF-β signaling in cancer.
Publication TypeJournal Article
Year of Publication2013
AuthorsKatz LH, Li Y, Chen J-S, Muñoz NM, Majumdar A, Chen J, Mishra L
JournalExpert opinion on therapeutic targets
Volume17
Issue7
Pagination743-60
Date Published2013 Jul
Abstract

The transforming growth factor-β (TGF-β) signaling pathway has a pivotal role in tumor suppression and yet, paradoxically, in tumor promotion. Functional context dependent insights into the TGF-β pathway are crucial in developing TGF-β-based therapeutics for cancer.

DOI10.1093/infdis/jit410
Alternate JournalExpert Opin. Ther. Targets