Targeting the c-Met pathway potentiates glioblastoma responses to gamma-radiation.

TitleTargeting the c-Met pathway potentiates glioblastoma responses to gamma-radiation.
Publication TypeJournal Article
Year of Publication2005
AuthorsLal B, Xia S, Abounader R, Laterra J
JournalClinical cancer research : an official journal of the American Association for Cancer Research
Volume11
Issue12
Pagination4479-86
Date Published2005 Jun 15
Abstract

Resistance to current cytotoxic therapies limits the treatment of most solid malignancies. This results, in part, from the overactivation of receptor tyrosine kinases and their downstream pathways in tumor cells and their associated vasculature. In this report, we ask if targeting the multifunctional mitogenic, cytoprotective, and angiogenic scatter factor/hepatocyte growth factor (SF/HGF)/c-Met pathway potentiates antitumor responses to gamma-radiation.

Alternate JournalClin. Cancer Res.