Synthesis of fluorine-containing multisubstituted phenanthridines by rhodium-catalyzed alkyne [2+2+2] cycloaddition and tandem sp² C-H difluoromethylenation.

TitleSynthesis of fluorine-containing multisubstituted phenanthridines by rhodium-catalyzed alkyne [2+2+2] cycloaddition and tandem sp² C-H difluoromethylenation.
Publication TypeJournal Article
Year of Publication2013
AuthorsLi Y, Zhu J, Zhang L, Wu Y, Gong Y
JournalChemistry (Weinheim an der Bergstrasse, Germany)
Volume19
Issue25
Pagination8294-9
Date Published2013 Jun 17
Abstract

A highly efficient method for the synthesis of fluorine-containing multisubstituted phenanthridines through Rh-catalyzed alkyne [2+2+2] cycloaddition reactions has been developed. This method exhibits excellent functional-group compatibility. When a bromodifluoromethyl group, rather than a trifluoromethyl group, was employed in the cycloaddition reaction, more-complicated polycyclic compounds were obtained through tandem Rh-catalyzed cycloaddition/C-H difluoromethylenation. This route provides convenient access to fluorine-containing polycyclic compounds.

DOI10.3978/j.issn.2072-1439.2013.08.53
Alternate JournalChemistry