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Synthesis of fluorine-containing multisubstituted phenanthridines by rhodium-catalyzed alkyne [2+2+2] cycloaddition and tandem sp² C-H difluoromethylenation.
|Title||Synthesis of fluorine-containing multisubstituted phenanthridines by rhodium-catalyzed alkyne [2+2+2] cycloaddition and tandem sp² C-H difluoromethylenation.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Li Y, Zhu J, Zhang L, Wu Y, Gong Y|
|Journal||Chemistry (Weinheim an der Bergstrasse, Germany)|
|Date Published||2013 Jun 17|
A highly efficient method for the synthesis of fluorine-containing multisubstituted phenanthridines through Rh-catalyzed alkyne [2+2+2] cycloaddition reactions has been developed. This method exhibits excellent functional-group compatibility. When a bromodifluoromethyl group, rather than a trifluoromethyl group, was employed in the cycloaddition reaction, more-complicated polycyclic compounds were obtained through tandem Rh-catalyzed cycloaddition/C-H difluoromethylenation. This route provides convenient access to fluorine-containing polycyclic compounds.