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Subtype B was the dominant strain among HIV type 1 infections except for the population of men who have sex with men in Harbin City, China.
|Title||Subtype B was the dominant strain among HIV type 1 infections except for the population of men who have sex with men in Harbin City, China.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Shao B, Li W-J, Liu T, Li Q-H, Li H, Chang M-L, Huang C-Q, Wang F-X, Wang B-Y|
|Journal||AIDS research and human retroviruses|
|Date Published||2013 Sep|
We sought to identify the prevalent subtypes and study the genetic variation of HIV-1 circulating in HIV infections in Harbin City, China. Forty-seven samples from the env V3-V4 region were successfully sequenced and analyzed, which involved thirty-one men who have sex with men (MSM), eight heterosexuals, seven former plasma donors (FPD)/blood transfusion recipients (BT), and one injection drug user (IDU). In all, 46.8% of CRF01_AE, 40.4% of subtype B, and 12.8% of CRF07_BC were identified. CRF01_AE (64.5%) was the dominant strain in MSM, and subtype B (81.2%) was the chief strain in other infected subjects except for the MSM population. Among all the genotypes, the B subtype possesses greater diversity of the tetramer on the tip of V3 loop than CRF07_BC and CRF01_AE, in which the peculiar GWGR was commonly found. Because nationwide there is a trend toward the increasing presence of CRF01_AE, a consecutive surveillance campaign was necessary among all HIV vulnerable populations in this locality.
|Alternate Journal||AIDS Res. Hum. Retroviruses|