Studying the emergence of autism spectrum disorders in high-risk infants: methodological and practical issues.

TitleStudying the emergence of autism spectrum disorders in high-risk infants: methodological and practical issues.
Publication TypeJournal Article
Year of Publication2007
AuthorsZwaigenbaum L, Thurm A, Stone W, Baranek G, Bryson S, Iverson J, Kau A, Klin A, Lord C, Landa R, Rogers S, Sigman M
JournalJournal of autism and developmental disorders
Volume37
Issue3
Pagination466-80
Date Published2007 Mar
Abstract

Detecting early signs of autism is essential for timely diagnosis and initiation of effective interventions. Several research groups have initiated prospective studies of high-risk populations including infant siblings, to systematically collect data on early signs within a longitudinal design. Despite the potential advantages of prospective studies of young children at high-risk for autism, there are also significant methodological, ethical and practical challenges. This paper outlines several of these challenges, including those related to sampling (e.g., defining appropriate comparison groups), measurement and clinical implications (e.g., addressing the needs of infants suspected of having early signs). We suggest possible design and implementation strategies to address these various challenges, based on current research efforts in the field and previous studies involving high-risk populations.

DOI10.3174/ajnr.A3505
Alternate JournalJ Autism Dev Disord