News & Updates
Search Research Content
Resource Finder at Kennedy Krieger Institute
A free resource that provides access to information and support for individuals and families living with developmental disabilities.
Studies on antibacterial mechanisms of copper complexes with 1,10-phenanthroline and amino acid on Escherichia coli.
|Title||Studies on antibacterial mechanisms of copper complexes with 1,10-phenanthroline and amino acid on Escherichia coli.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Liu X, Li X, Zhang Z, Dong Y, Liu P, Zhang C|
|Journal||Biological trace element research|
|Date Published||2013 Jul|
The antibacterial mechanisms of Cu(phen)2Cl2·6H2O, [Cu(phen)(Gly)(H2O)]Cl·3H2O, [Cu(phen)(L-Ser)(H2O)Cl] (1,10-phenanthroline (phen)) on Escherichia coli were investigated. In the inductively coupled plasma atomic emission spectroscopy experiments, it showed that lipophilic phen ligand can cause elevation of intracellular copper, but intracellular copper is not the decisive factor. The UV-vis and gel electrophoresis experiments reveal that the DNA binding and cleavage activity are decisive factors for the antibacterial action of these compounds. It is revealed by the cyclic voltammetry experiments that the redox potential was bound to the cleave activity.
|Alternate Journal||Biol Trace Elem Res|