Studies on antibacterial mechanisms of copper complexes with 1,10-phenanthroline and amino acid on Escherichia coli.

TitleStudies on antibacterial mechanisms of copper complexes with 1,10-phenanthroline and amino acid on Escherichia coli.
Publication TypeJournal Article
Year of Publication2013
AuthorsLiu X, Li X, Zhang Z, Dong Y, Liu P, Zhang C
JournalBiological trace element research
Volume154
Issue1
Pagination150-5
Date Published2013 Jul
Abstract

The antibacterial mechanisms of Cu(phen)2Cl2·6H2O, [Cu(phen)(Gly)(H2O)]Cl·3H2O, [Cu(phen)(L-Ser)(H2O)Cl] (1,10-phenanthroline (phen)) on Escherichia coli were investigated. In the inductively coupled plasma atomic emission spectroscopy experiments, it showed that lipophilic phen ligand can cause elevation of intracellular copper, but intracellular copper is not the decisive factor. The UV-vis and gel electrophoresis experiments reveal that the DNA binding and cleavage activity are decisive factors for the antibacterial action of these compounds. It is revealed by the cyclic voltammetry experiments that the redox potential was bound to the cleave activity.

DOI10.3324/haematol.2012.081083
Alternate JournalBiol Trace Elem Res