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Structures and biosynthesis of 12-membered macrocyclic depsipeptides from Streptomyces sp. ML55.
|Title||Structures and biosynthesis of 12-membered macrocyclic depsipeptides from Streptomyces sp. ML55.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Li X, Zvanych R, Torchia J, Magarvey NA|
|Journal||Bioorganic & medicinal chemistry letters|
|Date Published||2013 Jul 15|
Two novel depsipeptides (1-2) were isolated from Streptomyces sp. ML55 together with two known analogues (3-4). Their structures were elucidated using a combination of NMR experiments, as well as detailed MS/MS experiments. The biosynthetic pathway of isolated compounds was dissected by genome sequencing data analysis for a hybrid nonribosomal peptide synthetase (NRPS) and polyketide synthetase (PKS) assembly line.
|Alternate Journal||Bioorg. Med. Chem. Lett.|