Structures and biosynthesis of 12-membered macrocyclic depsipeptides from Streptomyces sp. ML55.

TitleStructures and biosynthesis of 12-membered macrocyclic depsipeptides from Streptomyces sp. ML55.
Publication TypeJournal Article
Year of Publication2013
AuthorsLi X, Zvanych R, Torchia J, Magarvey NA
JournalBioorganic & medicinal chemistry letters
Volume23
Issue14
Pagination4150-3
Date Published2013 Jul 15
Abstract

Two novel depsipeptides (1-2) were isolated from Streptomyces sp. ML55 together with two known analogues (3-4). Their structures were elucidated using a combination of NMR experiments, as well as detailed MS/MS experiments. The biosynthetic pathway of isolated compounds was dissected by genome sequencing data analysis for a hybrid nonribosomal peptide synthetase (NRPS) and polyketide synthetase (PKS) assembly line.

DOI10.1155/2013/724183
Alternate JournalBioorg. Med. Chem. Lett.