Striatum-based circuitry of adolescent depression and anhedonia.

TitleStriatum-based circuitry of adolescent depression and anhedonia.
Publication TypeJournal Article
Year of Publication2013
AuthorsGabbay V, Ely BA, Li Q, Bangaru SD, Panzer AM, Alonso CM, Castellanos XF, Milham MP
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Date Published2013 Jun

Striatum-based circuits have been implicated in both major depressive disorder (MDD) and anhedonia, a symptom that reflects deficits of reward processing. Yet adolescents with MDD often exhibit a wide range of anhedonia severity. Addressing this clinical phenomenon, we aimed to use intrinsic functional connectivity (iFC) to study striatum-based circuitry in relation to categorical diagnosis of MDD and anhedonia severity.

Alternate JournalJ Am Acad Child Adolesc Psychiatry