Spironolactone Attenuates Bleomycin-Induced Pulmonary Injury Partially via Modulating Mononuclear Phagocyte Phenotype Switching in Circulating and Alveolar Compartments.

TitleSpironolactone Attenuates Bleomycin-Induced Pulmonary Injury Partially via Modulating Mononuclear Phagocyte Phenotype Switching in Circulating and Alveolar Compartments.
Publication TypeJournal Article
Year of Publication2013
AuthorsJi W-J, Ma Y-Q, Zhou X, Zhang Y-D, Lu R-Y, Guo Z-Z, Sun H-Y, Hu D-C, Yang G-H, Li Y-M, Wei L-Q
JournalPloS one
Volume8
Issue11
Paginatione81090
Date Published2013
Abstract

Recent experimental studies provide evidence indicating that manipulation of the mononuclear phagocyte phenotype could be a feasible approach to alter the severity and persistence of pulmonary injury and fibrosis. Mineralocorticoid receptor (MR) has been reported as a target to regulate macrophage polarization. The present work was designed to investigate the therapeutic potential of MR antagonism in bleomycin-induced acute lung injury and fibrosis.

DOI10.1039/c3cc46574h
Alternate JournalPLoS ONE