Sphingomyelin synthase 2 activity and liver steatosis: an effect of ceramide-mediated peroxisome proliferator-activated receptor γ2 suppression.

TitleSphingomyelin synthase 2 activity and liver steatosis: an effect of ceramide-mediated peroxisome proliferator-activated receptor γ2 suppression.
Publication TypeJournal Article
Year of Publication2013
AuthorsLi Y, Dong J, Ding T, Kuo M-S, Cao G, Jiang X-C, Li Z
JournalArteriosclerosis, thrombosis, and vascular biology
Volume33
Issue7
Pagination1513-20
Date Published2013 Jul
Abstract

Sphingolipid de novo biosynthesis is related to nonalcoholic fatty liver disease or hepatic steatosis. However, the mechanism is still unclear. Sphingomyelin synthase (SMS), using ceramide as one of the substrates to produce sphingomyelin, sits at the crossroads of sphingolipid biosynthesis. SMS has 2 isoforms: SMS1 and SMS2. SMS2 is the major isoform in liver.

DOI10.3290/j.qi.a30177
Alternate JournalArterioscler. Thromb. Vasc. Biol.