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Sphingomyelin synthase 2 activity and liver steatosis: an effect of ceramide-mediated peroxisome proliferator-activated receptor γ2 suppression.
|Title||Sphingomyelin synthase 2 activity and liver steatosis: an effect of ceramide-mediated peroxisome proliferator-activated receptor γ2 suppression.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Li Y, Dong J, Ding T, Kuo M-S, Cao G, Jiang X-C, Li Z|
|Journal||Arteriosclerosis, thrombosis, and vascular biology|
|Date Published||2013 Jul|
Sphingolipid de novo biosynthesis is related to nonalcoholic fatty liver disease or hepatic steatosis. However, the mechanism is still unclear. Sphingomyelin synthase (SMS), using ceramide as one of the substrates to produce sphingomyelin, sits at the crossroads of sphingolipid biosynthesis. SMS has 2 isoforms: SMS1 and SMS2. SMS2 is the major isoform in liver.
|Alternate Journal||Arterioscler. Thromb. Vasc. Biol.|