SNP rs3825214 in TBX5 is associated with lone atrial fibrillation in Chinese Han population.

TitleSNP rs3825214 in TBX5 is associated with lone atrial fibrillation in Chinese Han population.
Publication TypeJournal Article
Year of Publication2013
AuthorsZang X, Zhang S, Xia Y, Li S, Fu F, Li X, Wang F, Zhang R, Tian X, Gao L, Zhang J, Yang Y, Tu X, Wang Q
JournalPloS one
Volume8
Issue5
Paginatione64966
Date Published2013
Abstract

A prolonged PR interval is a sign of increased risk of cardiac arrhythmia. Recent genome-wide association studies found that the single-nucleotide polymorphism (SNP) rs3825214 in T-box 5 (TBX5) was positively associated with PR interval, QRS duration, QT interval, and common arrhythmia disorders such as atrial fibrillation (AF) and advanced atrioventricular block. However, other independent replication studies are required to validate the result. This study assessed associations between rs3825214 and ECG parameters, AF, and ventricular tachycardia (VT) in a Chinese Han population.

DOI10.3978/j.issn.2225-319X.2013.07.23
Alternate JournalPLoS ONE