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SNOMAD (Standardization and NOrmalization of MicroArray Data): web-accessible gene expression data analysis.
|Title||SNOMAD (Standardization and NOrmalization of MicroArray Data): web-accessible gene expression data analysis.|
|Publication Type||Journal Article|
|Year of Publication||2002|
|Authors||Colantuoni C, Henry G, Zeger S, Pevsner J|
|Journal||Bioinformatics (Oxford, England)|
|Date Published||2002 Nov|
SNOMAD is a collection of algorithms for the normalization and standardization of gene expression datasets derived from diverse biological and technological sources. In addition to conventional transformations and visualization tools, SNOMAD includes two non-linear transformations which correct for bias and variance which are non-uniformly distributed across the range of microarray element signal intensities: (1). Local mean normalization; and (2). Local variance correction (Z-score generation using a locally calculated standard deviation).