SKP2 high expression, KIT exon 11 deletions, and gastrointestinal bleeding as predictors of poor prognosis in primary gastrointestinal stromal tumors.

TitleSKP2 high expression, KIT exon 11 deletions, and gastrointestinal bleeding as predictors of poor prognosis in primary gastrointestinal stromal tumors.
Publication TypeJournal Article
Year of Publication2013
AuthorsLv A, Li Z, Tian X, Guan X, Zhao M, Dong B, Hao C
JournalPloS one
Volume8
Issue5
Paginatione62951
Date Published2013
Abstract

Considering the indication of adjuvant therapy, the recurrence risk for primary gastrointestinal stromal tumor (GIST) after surgery needs to be accurately estimated. However, current risk stratification schemes may still have room for improvement. This study seeks to analyze prognostic factors for primary GISTs from 3 aspects, including clinicopathological parameters, immunohistochemical biomarkers, and gene mutational status, and attempts to find novel valuable factors predicting the malignancy potential of GISTs.

DOI10.1371/journal.pone.0064589
Alternate JournalPLoS ONE