Shear stress regulates late EPC differentiation via mechanosensitive molecule-mediated cytoskeletal rearrangement.

TitleShear stress regulates late EPC differentiation via mechanosensitive molecule-mediated cytoskeletal rearrangement.
Publication TypeJournal Article
Year of Publication2013
AuthorsCheng M, Guan X, Li H, Cui X, Zhang X, Li X, Jing X, Wu H, Avsar E
JournalPloS one
Volume8
Issue7
Paginatione67675
Date Published2013
Abstract

Previous studies have demonstrated that endothelial progenitor cells (EPCs), in particular late EPCs, play important roles in endothelial maintenance and repair. Recent evidence has revealed shear stress as a key regulator for EPC differentiation. However, the underlying mechanisms regulating the shear stress-induced EPC differentiation have not been understood completely. The present study was undertaken to further investigate the effects of shear stress on the late EPC differentiation, and to elucidate the signal mechanism involved.

DOI10.1371/journal.pone.0068568
Alternate JournalPLoS ONE