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Semisynthetic lipidated LC3 protein mediates membrane fusion.
|Title||Semisynthetic lipidated LC3 protein mediates membrane fusion.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Yang A, Li Y, Pantoom S, Triola G, Wu Y-W|
|Journal||Chembiochem : a European journal of chemical biology|
|Date Published||2013 Jul 22|
All together: Lipidated LC3 has been synthesized by expressed protein ligation. A TEV-cleavable MBP tag was employed to facilitate ligation under folding conditions and to solubilize the lipidated protein. The synthetic LC3-phosphatidylethanolamine (PE) mediates membrane tethering and fusion at the physiological concentration of PE, and could be a useful tool for autophagy studies.