Self-adjuvanting synthetic antitumor vaccines from MUC1 glycopeptides conjugated to T-cell epitopes from tetanus toxoid.

TitleSelf-adjuvanting synthetic antitumor vaccines from MUC1 glycopeptides conjugated to T-cell epitopes from tetanus toxoid.
Publication TypeJournal Article
Year of Publication2013
AuthorsCai H, Chen M-S, Sun Z-Y, Zhao Y-F, Kunz H, Li Y-M
JournalAngewandte Chemie (International ed. in English)
Volume52
Issue23
Pagination6106-10
Date Published2013 Jun 3
Abstract

The T-helper epitope peptide P30 (green in the scheme) from tetanus toxoid was used as the immunostimulant in MUC1 glycopeptide antitumor vaccines and apparently also acts as a built-in adjuvant. P30-conjugated glycopeptide vaccines containing three glycans in the immunodominant motifs PDTRP and GSTAP induced much stronger immune responses and complement dependent cytotoxicity mediated killing of tumor cells when applied in plain PBS solution without complete Freund's adjuvant.

DOI10.1007/s13181-013-0310-2
Alternate JournalAngew. Chem. Int. Ed. Engl.