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Role of cyclic nucleotides in fetal hemoglobin induction in cultured CD34+ cells.
|Title||Role of cyclic nucleotides in fetal hemoglobin induction in cultured CD34+ cells.|
|Publication Type||Journal Article|
|Year of Publication||2006|
|Authors||Keefer JR, Schneidereith TA, Mays A, Purvis SH, Dover GJ, Smith KD|
|Date Published||2006 Sep|
In vivo, several drugs have been shown to increase fetal hemoglobin (HbF), including 5-azacytidine (AZA), sodium butyrate (SB), and hydroxyurea (HU). Studies in K562 cells suggest that cyclic guanosine monophosphate (cGMP) is required for HbF induction; however, the role of cyclic nucleotides in HbF induction in primary erythroid cultures has not been established.
|Alternate Journal||Exp. Hematol.|