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Role of cyclic nucleotides in fetal hemoglobin induction in cultured CD34+ cells.
| Title | Role of cyclic nucleotides in fetal hemoglobin induction in cultured CD34+ cells. |
| Publication Type | Journal Article |
| Year of Publication | 2006 |
| Authors | Keefer JR, Schneidereith TA, Mays A, Purvis SH, Dover GJ, Smith KD |
| Journal | Experimental hematology |
| Volume | 34 |
| Issue | 9 |
| Pagination | 1151-61 |
| Date Published | 2006 Sep |
| Abstract | In vivo, several drugs have been shown to increase fetal hemoglobin (HbF), including 5-azacytidine (AZA), sodium butyrate (SB), and hydroxyurea (HU). Studies in K562 cells suggest that cyclic guanosine monophosphate (cGMP) is required for HbF induction; however, the role of cyclic nucleotides in HbF induction in primary erythroid cultures has not been established. |
| Alternate Journal | Exp. Hematol. |
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